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4-isopropyl-2-(2-hydroxyanilino)tropone

cytotoxic; structure in first source

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cycloheptanes
        Tropolone: 44
        4-isopropyl-2-(2-hydroxyanilino)tropone: 2

Experts

1.	Narita, Taichi: 2 articles (01/2010 - 04/2009)
2.	Sakagami, Hiroshi: 2 articles (01/2010 - 04/2009)
3.	Suga, Akina: 2 articles (01/2010 - 04/2009)
4.	Wakabayashi, Hidetsugu: 2 articles (01/2010 - 04/2009)
5.	Hashimoto, Ken: 1 article (04/2009)
6.	Kobayashi, Masaki: 1 article (04/2009)
7.	Kurihara, Teruo: 1 article (04/2009)
8.	Motohashi, Noboru: 1 article (04/2009)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2010 - "We have recently reported that out of twenty benzo[b]cyclohept[e][1,4]oxazines and their S-analogs, and 2-aminotropone derivatives, 7-bromo-2-(4-hydroxyanilino) tropone and 4-isopropyl-2-(2-hydroxyanilino)tropone showed the highest tumor-specificity in human oral squamous cell carcinoma cell lines. "
2.	Leukemia 04/01/2009 - "The highly active derivatives, 7-bromo-2-(4-hydroxyanilino)tropone [16] and 4-isopropyl-2-(2-hydroxyanilino)tropone [20], induced internucleosomal DNA fragmentation and caspase-3, -8 and -9 activation in human promyelocytic leukemia HL-60 cells, but only at concentrations twice or four times higher than CC(50) values. "
3.	Squamous Cell Carcinoma of Head and Neck 01/01/2010 - "We have recently reported that out of twenty benzo[b]cyclohept[e][1,4]oxazines and their S-analogs, and 2-aminotropone derivatives, 7-bromo-2-(4-hydroxyanilino) tropone and 4-isopropyl-2-(2-hydroxyanilino)tropone showed the highest tumor-specificity in human oral squamous cell carcinoma cell lines. "

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	Oxazines
3.	7-bromo-2-(4-hydroxyanilino)tropone
4.	2-aminotropone
5.	tropone