PMI-5011

an ethanolic extract of Artemisia dracunculus that is hypoglycemic in animal models for Type 2 diabetes and contains at least 6 bioactive compounds responsible for its anti-diabetic properties

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Ribnicky, David M: 4 articles (07/2015 - 03/2009)
2.	Cefalu, William T: 3 articles (01/2011 - 03/2009)
3.	Obrosova, Irina G: 2 articles (03/2011 - 01/2010)
4.	Stavniichuk, Roman: 2 articles (03/2011 - 01/2010)
5.	Watcho, Pierre: 2 articles (03/2011 - 01/2010)
6.	Zuberi, Aamir: 2 articles (01/2011 - 03/2009)
7.	Raskin, Ilya: 2 articles (01/2010 - 03/2009)
8.	Dang, T N: 1 article (11/2021)
9.	Floyd, Z E: 1 article (11/2021)
10.	Kuhn, P: 1 article (11/2021)

Related Diseases

1.	Peripheral Nervous System Diseases (PNS Diseases) 03/01/2011 - "This study evaluated PMI-5011 on established functional, structural, and biochemical changes associated with Type I diabetic peripheral neuropathy. " 03/01/2011 - "In conclusion, PMI-5011, a safe and non-toxic botanical extract, may find use in the treatment of diabetic peripheral neuropathy." 03/01/2011 - "Evaluation of PMI-5011, an ethanolic extract of Artemisia dracunculus L., on peripheral neuropathy in streptozotocin-diabetic mice." 03/01/2011 - "We previously reported that PMI-5011, an ethanolic extract of Artemisia dracunculus L., alleviates peripheral neuropathy in high fat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and pro-inflammatory changes in the peripheral nervous system. "
2.	Prediabetic State (Prediabetes) 01/01/2010 - "We evaluated PMI-5011, an ethanolic extract of Artemisia dracunculus L., on neuropathy in high-fat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and proinflammatory changes in peripheral nervous system. " 01/01/2010 - "High-fat diet-induced neuropathy of prediabetes and obesity: effect of PMI-5011, an ethanolic extract of Artemisia dracunculus L." 03/01/2011 - "We previously reported that PMI-5011, an ethanolic extract of Artemisia dracunculus L., alleviates peripheral neuropathy in high fat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and pro-inflammatory changes in the peripheral nervous system. "
3.	Obesity 01/01/2010 - "We evaluated PMI-5011, an ethanolic extract of Artemisia dracunculus L., on neuropathy in high-fat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and proinflammatory changes in peripheral nervous system. " 01/01/2010 - "High-fat diet-induced neuropathy of prediabetes and obesity: effect of PMI-5011, an ethanolic extract of Artemisia dracunculus L." 03/01/2011 - "We previously reported that PMI-5011, an ethanolic extract of Artemisia dracunculus L., alleviates peripheral neuropathy in high fat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and pro-inflammatory changes in the peripheral nervous system. "
4.	Type 2 Diabetes Mellitus (MODY) 11/01/2021 - "Thus, the AMPK-activating potential of the KOE adds therapeutic value to PMI-5011 and its constituents in treating insulin resistance or type 2 diabetes." 09/01/2010 - "To determine the mechanism of action of PMI-5011, we have measured changes in protein expression in human primary skeletal muscle culture (HSMC) from subjects with Type 2 diabetes. "
5.	Body Weight (Weight, Body) 03/31/2009 - "To evaluate the bioavailability of the active compounds, high fat dietary induced obese C57BL/6J male mice were gavaged with PMI-5011 at 500mg/kg body weight, after 4h of food restriction. " 01/01/2011 - "In vivo, PMI-5011 increased Agrp promoter activity in luciferase-expressing transgenic mice, increased hypothalamic Klf4 and Agrp expression, increased hypothalamic Orexin and melanin-concentrating hormone, increased food intake, reduced circulating insulin and leptin levels, attenuated energy expenditure, and enhanced body weight but only when using a high-fat diet. "

Related Drugs and Biologics

1.	Insulin (Novolin)
2.	Leptin
3.	Streptozocin (Streptozotocin)
4.	Sorbitol (Yal)
5.	Proteins (Proteins, Gene)
6.	Luciferases
7.	Dietary Fats (Dietary Fat)
8.	Cell Extracts
9.	Arachidonate 15-Lipoxygenase (Arachidonate 15 Lipoxygenase)
10.	Deubiquitinating Enzymes