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N,N''- 1,4- butanediylbis(N'- (3- isothiocyanatophenyl))thiourea

a P2Y6 receptor antagonist

Also Known As:

MRS 2578; MRS-2578; MRS2578

Networked: 24 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Liu, Mingyao: 2 articles (01/2022 - 02/2016)
2.	Chen, Jingyuan: 2 articles (01/2020 - 01/2020)
3.	Du, Xiao: 2 articles (01/2020 - 01/2020)
4.	Li, Xin: 2 articles (01/2020 - 01/2020)
5.	Liu, Ling: 2 articles (01/2020 - 01/2020)
6.	Tan, Yuansheng: 2 articles (01/2020 - 01/2020)
7.	Tian, Feng: 2 articles (01/2020 - 01/2020)
8.	Xiang, Qunyan: 2 articles (01/2020 - 01/2020)
9.	Xu, Jin: 2 articles (01/2020 - 01/2020)
10.	Zhang, Shilan: 2 articles (01/2020 - 01/2020)

Related Diseases

1.	Neuralgia (Stump Neuralgia) 10/01/2019 - "To explore the role of P2Y6 receptors in the maintenance of neuropathic pain and progression of oxidative stress, we investigated the efficacy of the selective P2Y6 receptors antagonist MRS2578 on the antiallodynic effects and improvement of pathological neuropathic pain-induced oxidative stress, thereby finding a potential therapeutic target in neurological disease. " 09/01/2014 - "However, systemic and intrathecal administration of the P2Y6 receptor antagonist MRS2578 failed to affect the injury-induced neuropathic pain behavior. "
2.	Inflammation (Inflammations) 01/01/2023 - "In this article, we systematically summarize the role of P2Y6R in inflammation and highlight the anti-inflammatory mechanism of a key P2Y6R antagonist, MRS2578. " 07/15/2011 - "MRS2578 was also effective in reducing airway inflammation in a model using house dust mite extracts to induce allergic lung inflammation. "
3.	Pneumonia (Pneumonitis) 07/15/2011 - "MRS2578 was also effective in reducing airway inflammation in a model using house dust mite extracts to induce allergic lung inflammation. "
4.	Rupture 01/01/2020 - "Treatment with MRS2578 made no significant difference in AAA formation, and maximal aortic diameter yet caused higher AAA rupture-induced mortality from 7% (Ang II) to 21.4% (Ang II+MRS-16 mg) or 42.9% (Ang II+MRS-32 mg), respectively (p < 0.05). " 01/01/2020 - "The present study demonstrated that administration of MRS2578 exacerbated the progression and rupture of experimental AAA through promoting proinflammatory response and MMP expression and activity, which indicated a crucial role of the P2Y6 receptor in AAA development. "
5.	Alcoholic Fatty Liver 08/01/2022 - "In this study, mice with alcoholic steatohepatitis were intraperitoneally injected with MRS2578, a specific inhibitor of the P2Y6 receptor, and P2Y6 was silenced in EtOH-induced RAW264.7 cells. "

Related Drugs and Biologics

1.	purinoceptor P2Y6
2.	Matrix Metalloproteinases (MMPs)
3.	Uridine Diphosphate (UDP)
4.	Angiotensin II
5.	Small Interfering RNA (siRNA)
6.	Neuroprotective Agents
7.	Interleukin-10 (Interleukin 10)
8.	Oxidopamine (6 Hydroxydopamine)
9.	Cytokines
10.	Interleukin-6 (Interleukin 6)

Related Therapies and Procedures

1.	Spinal Injections