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3- (9- methoxy- 5,11- dimethylpyrido(4,3- b)carbazol- 6- yl)propan- 1- amine

has antineoplastic activity; structure in first source

Also Known As:

NSC 176327; NSC-176327; NSC176327

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	El-Deiry, Wafik S: 1 article (12/2008)
2.	Lu, Chao: 1 article (12/2008)
3.	Wang, Wenge: 1 article (12/2008)

Related Diseases

1.	Neoplasms (Cancer) 12/01/2008 - "These results demonstrate an important role of p73 in the anti-tumor effects of NSC176327,and suggest that a close analogue of ellipticine may act by a non-genotoxic mechanism targeting the p53/p73 pathway as compared to the original parent compound that targets the same pathway." 12/01/2008 - "NSC176327 was more potent at inhibiting tumor cell growth as compared to chemotherapeutic drugs and other ellipticine derivatives and induced cell cycle arrest and apoptosis. " 12/01/2008 - "Here we further examined the anti-tumor effects of selected compounds in vitro and showed that NSC176327, a derivative of the cytotoxic plant alkaloid ellipticine, exhibited strong anti-neoplastic effect sin wild-type p53, p53-mutant or p53-deficient human colon cancer cells. " 12/01/2008 - "Surprisingly, unlike what is observed with the parent compound ellipticine, a DNA damage signaling response was not observed with NSC176327 as evidenced by lack of phosphorylated histone H2AX foci in NSC176327-treated tumor cells. "
2.	Colonic Neoplasms (Colon Cancer) 12/01/2008 - "Here we further examined the anti-tumor effects of selected compounds in vitro and showed that NSC176327, a derivative of the cytotoxic plant alkaloid ellipticine, exhibited strong anti-neoplastic effect sin wild-type p53, p53-mutant or p53-deficient human colon cancer cells. "
3.	Carcinoma (Carcinomatosis) 12/01/2008 - "Non-genotoxic anti-neoplastic effects of ellipticine derivative NSC176327 in p53-deficient human colon carcinoma cells involve stimulation of p73."

Related Drugs and Biologics

1.	A-Form DNA (A-DNA)
2.	Histones (Histone)
3.	Alkaloids
4.	ellipticine