|1.||Wang, Wenge: 1 article (12/2008)|
|2.||Lu, Chao: 1 article (12/2008)|
|3.||El-Deiry, Wafik S: 1 article (12/2008)|
12/01/2008 - "These results demonstrate an important role of p73 in the anti-tumor effects of NSC176327,and suggest that a close analogue of ellipticine may act by a non-genotoxic mechanism targeting the p53/p73 pathway as compared to the original parent compound that targets the same pathway."
12/01/2008 - "NSC176327 was more potent at inhibiting tumor cell growth as compared to chemotherapeutic drugs and other ellipticine derivatives and induced cell cycle arrest and apoptosis. "
12/01/2008 - "Here we further examined the anti-tumor effects of selected compounds in vitro and showed that NSC176327, a derivative of the cytotoxic plant alkaloid ellipticine, exhibited strong anti-neoplastic effect sin wild-type p53, p53-mutant or p53-deficient human colon cancer cells. "
12/01/2008 - "Surprisingly, unlike what is observed with the parent compound ellipticine, a DNA damage signaling response was not observed with NSC176327 as evidenced by lack of phosphorylated histone H2AX foci in NSC176327-treated tumor cells. "
|2.||Colonic Neoplasms (Colon Cancer)
|1.||A-Form DNA (A-DNA)