PCERA-1

a ceramide-1-phosphate analog that simultaneously suppresses tumour necrosis factor-alpha and induces interleukin-10 production in activated macrophages; structure in first source

Also Known As:

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Meijler, Michael M: 4 articles (03/2017 - 03/2009)
2.	Zor, Tsaffrir: 4 articles (03/2017 - 03/2009)
3.	Ernst, Orna: 3 articles (03/2017 - 03/2009)
4.	Mashiach, Roi: 3 articles (03/2017 - 03/2009)
5.	Avni, Dorit: 3 articles (03/2010 - 03/2009)
6.	Goldsmith, Meir: 2 articles (05/2009 - 03/2009)
7.	Gray, Nathanael S: 2 articles (05/2009 - 03/2009)
8.	Rosen, Hugh: 2 articles (05/2009 - 03/2009)
9.	Adepu, Raju: 1 article (03/2017)
10.	Athamna, Muhammad: 1 article (03/2017)

Related Diseases

1.	Inflammation (Inflammations) 03/30/2017 - "Phospho-ceramide analogue-1 (PCERA-1), a synthetic analogue of ceramide-1-phosphate (C1P), has been previously shown to act as a potent modulator of macrophage activity and inflammation. " 05/01/2009 - "Thus, identification of the PCERA-1 receptor may provide new pharmacological means to block inflammation." 03/24/2009 - "The independent and reciprocal modulation of production of TNFalpha and IL-12p40, vs. IL-10, suggests that PCERA-1 may be a candidate drug for the treatment of inflammation-linked diseases."
2.	Necrosis 05/01/2009 - "A ceramide-1-phosphate analogue, PCERA-1, simultaneously suppresses tumour necrosis factor-alpha and induces interleukin-10 production in activated macrophages." 03/01/2010 - "The ceramide-1-phosphate analogue PCERA-1 modulates tumour necrosis factor-alpha and interleukin-10 production in macrophages via the cAMP-PKA-CREB pathway in a GTP-dependent manner." 03/01/2010 - "The synthetic phospho-ceramide analogue-1 (PCERA-1) down-regulates production of the pro-inflammatory cytokine tumour necrosis factor-alpha (TNF-alpha) and up-regulates production of the anti-inflammatory cytokine interleukin-10 (IL-10) in lipopolysaccharide (LPS) -stimulated macrophages. "

Related Drugs and Biologics

1.	Interleukin-10 (Interleukin 10)
2.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
3.	Interleukin-12 Subunit p40
4.	Cytokines
5.	Lipopolysaccharides
6.	Guanosine Triphosphate (GTP)