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4- piperazin- 1- yl- 6,7- dihydro- 5H- benzo(6,7)cyclohepta(1,2- d)pyrimidin- 2- ylamine

a potent histamine H4 receptor antagonist; structure in first source

Also Known As:

A-940894

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - 4-piperazin-1-yl-6,7-dihydro-5H-benzo(6,7)cyclohepta(1,2-d)pyrimidin-2-ylamine: 1
  - Piperazines: 26
    - 4-piperazin-1-yl-6,7-dihydro-5H-benzo(6,7)cyclohepta(1,2-d)pyrimidin-2-ylamine: 1

Experts

1.	Adair, R M: 1 article (05/2009)
2.	Baranowski, J L: 1 article (05/2009)
3.	Bettencourt, B M: 1 article (05/2009)
4.	Brioni, J D: 1 article (05/2009)
5.	Brito, A A: 1 article (05/2009)
6.	Carr, T L: 1 article (05/2009)
7.	Cowart, M D: 1 article (05/2009)
8.	Cuff, C A: 1 article (05/2009)
9.	Esbenshade, T A: 1 article (05/2009)
10.	Liu, H: 1 article (05/2009)

Related Diseases

1.

05/01/2009 - "In a mouse mast cell-dependent model of zymosan-induced peritonitis, A-940894 significantly blocked neutrophil influx and reduced intraperitoneal prostaglandin D2 levels. "
05/01/2009 - "We have analysed the pharmacological profile of A-940894 at mouse native, rat recombinant and human recombinant and native, histamine H4 receptors by radioligand binding, calcium mobilization, mast cell shape change, eosinophil chemotaxis assays and in the mouse model of zymosan-induced peritonitis. "

Related Drugs and Biologics

1.	Prostaglandin D2
2.	Zymosan
3.	Calcium
4.	Histamine H4 Receptors