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N-Ac-CHAVC-NH2

antineoplastic; anti-N-cadherin cyclic pentapeptide that exerts a direct antitumor effect; in phase I trial 2/2009

Also Known As:

ADH-1 peptide; Exherin

Networked: 6 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - N-Ac-CHAVC-NH2: 6
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - N-Ac-CHAVC-NH2: 6

Experts

1.	Duan, Ruiqi: 1 article (01/2021)
2.	Guo, Ju: 1 article (01/2021)
3.	Hu, Hailiang: 1 article (01/2021)
4.	Jing, Jun: 1 article (01/2021)
5.	Liu, Shengzhuo: 1 article (01/2021)
6.	Sun, Yi: 1 article (01/2021)
7.	Tang, Cai: 1 article (01/2021)
8.	Wei, Qiang: 1 article (01/2021)
9.	Xu, Huan: 1 article (01/2021)
10.	Xu, Lingfan: 1 article (01/2021)

Related Diseases

1.	Ovarian Epithelial Carcinoma 03/07/2015 - "Compounds 2 and 3 inhibit adhesion of epithelial ovarian cancer (EOC) cells with improved efficacy compared to the ADH-1 peptide, a N-cadherin antagonist that is in early clinical trials in EOC patients."
2.	Neoplasms (Cancer) 02/01/2013 - "Phase I clinical trial of Exherin (ADH-1) in patients with advanced solid tumors." 11/01/2018 - "In this paper, ADH-1 peptide-modified liposomes (A-LP) have been successfully constructed for restoring chemosensitivity and suppressing cancer cell migration. " 01/01/2023 - "The N-cadherin-specific binding of [18F]AlF-NOTA-ADH-1 was further verified by a blocking experiment involving coinjection of a non radiolabeled ADH-1 peptide, resulting in a significant reduction in tumor uptake in PDX xenografts and SW480 tumor. " 01/01/2012 - "Treatment of NB cell lines with the N-cadherin blocking peptide ADH-1 (Exherin, Adherex Technologies Inc.), strongly inhibited tumor cell proliferation in vitro by inducing apoptosis. "
3.	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/01/2021 - "Then, we used PC3-bearing humanized non-obese diabetic/severe combined immunodeficiency IL2Rγnull (hNSG) mice with an intravenous injection of human CD34+ hematopoietic stem cells into the tail vein to evaluate whether the N-cadherin antagonist N-Ac-CHAVC-NH2 (designated ADH-1) could improve the therapeutic effect of tumor-infiltrating lymphocyte (TIL)-related treatment. "

Related Drugs and Biologics

1.	Cadherins (E-Cadherin)
2.	1,4,7- triazacyclononane- N,N',N''- triacetic acid (NOTA)
3.	Therapeutic Uses
4.	Peptides (Polypeptides)
5.	Liposomes (Liposome)

Related Therapies and Procedures

1.	Intravenous Injections