|1.||Quan, Zhe-Shan: 1 article (04/2009)|
|2.||Zhao, Dong-Hai: 1 article (04/2009)|
|3.||Jiang, Zhe: 1 article (04/2009)|
|4.||Guan, Li-Ping: 1 article (04/2009)|
|5.||Piao, Hu-Ri: 1 article (04/2009)|
04/01/2009 - "In addition, QUAN-0806 was found to exhibit significant oral activity against MES-induced seizures with low oral neurotoxicity in mice. "
04/01/2009 - "Evaluation of anticonvulsant activity of QUAN-0806 in various murine experimental seizure models."
04/01/2009 - "A new quinoline derivative, QUAN-0806 (7-hexyloxy-5-phenyl-1,2,4-triazolo[4,3-alpha]quinoline) was tested for anticonvulsant activity using the maximal electroshock seizure (MES) and the rotarod neurotoxicity (Tox) tests in mice. "
04/01/2009 - "QUAN-0806 produced significant antagonistic activity against seizures induced by PTZ, 3-MPA, and ISO, suggesting that QUAN-0806 influences GABAergic neurotransmission by activating glutamate decarboxylase (GAD) or inhibiting (GABA)-a-oxoglutarate aminotransferase (GABA-T) in the brain."
|1.||Glutamate Decarboxylase (Decarboxylase, Glutamate)
|2.||gamma-Aminobutyric Acid (GABA)
|3.||4-Aminobutyrate Transaminase (4 Aminobutyrate Transaminase)