azvudine

a reverse transcriptase inhibitor with antiviral activity

Also Known As:

2'-deoxy-2'-beta-fluoro-4'-azidocytidine; 4'-azido-2'-deoxy-2'-fluorocytidine; 4-amino-1-((2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-5-((imino-l,5-azanylidene)amino)tetrahydrofuran-2-yl)pyrimidin-2-one; 4-amino-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)-5-((imino-l,5-azanylidene)amino)tetrahydrofuran-2-yl)pyrimidin-2-one; RO-0622

Networked: 30 relevant articles (7 outcomes, 7 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Chang, Junbiao: 4 articles (01/2022 - 10/2020)
2.	Liu, Yong: 3 articles (12/2021 - 10/2020)
3.	Cui, Guangying: 2 articles (10/2020 - 10/2020)
4.	Dong, Lihong: 2 articles (10/2020 - 10/2020)
5.	Du, Jinfa: 2 articles (10/2020 - 10/2020)
6.	Hu, Chuansong: 2 articles (10/2020 - 10/2020)
7.	Li, Qingquan: 2 articles (10/2020 - 10/2020)
8.	Liang, Lan: 2 articles (10/2020 - 10/2020)
9.	Luo, Hong: 2 articles (10/2020 - 10/2020)
10.	Pei, Guangzhong: 2 articles (10/2020 - 10/2020)

Related Diseases

1.	COVID-19 12/06/2021 - "Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients." 01/01/2023 - "Background: Azvudine (FNC) is a promising treatment candidate for managing coronavirus disease 2019 (COVID-19). " 11/01/2023 - "Chest computed tomography (CT) scan reports also demonstrated that Azvudine treatment improved lung symptoms in COVID-19 hospitalized patients. " 09/01/2023 - "This study aimed to assess the COVID-19 treatment with azvudine's efficacy and safety. " 01/01/2023 - "Phase III, randomized, double-blind, placebo-controlled clinical study: a study on the safety and clinical efficacy of AZVUDINE in moderate COVID-19 patients."
2.	Disease Progression 01/01/2023 - "Our study found that Azvudine could reduce the rate of disease progression, as well as rate of COVID-19-related hospitalization in patients comparing the control group. " 05/01/2023 - "Azvudine treatment was associated with significantly lower risks of composite disease progression outcome compared with matched controls (HR: 0.49; 95% CI: 0.27-0.89, P = 0.016). " 05/01/2023 - "Azvudine recipients had lower crude incidence rate of composite disease progression outcome compared with matched controls (7.125/1000 person-days vs. 16.004/1000 person-days, P = 0.018). " 01/01/2023 - "Azvudine was associated with lower risks of composite disease progression outcome (hazard ratio [HR]: 0.55; 95% confidence interval [CI]: 0.32-0.94) and all-cause death (HR: 0.40; 95% CI: 0.16-1.04). " 01/01/2023 - "The lower crude incidence rate of composite disease progression outcome (7.83 vs. 14.83 per 1000 person-days, p = 0.026) and all-cause death (2.05 vs. 5.78 per 1000 person-days, p = 0.052) were observed among Azvudine recipients. "
3.	Critical Illness (Critically Ill) 07/23/2023 - "Paxlovid, Azvudine, and therapeutic anticoagulation showed a significant reduction in disability (p < 0.05) Conclusions: Among severely and critically ill patients with COVID-19 who received 1 or more therapeutic interventions, treatment with Azvudine had a high probability of improved 60-day mortality compared with the control, indicating its potential in a resource-limited scenario. "
4.	HIV Infections (HIV Infection) 01/01/2023 - "Furthermore, Azvudine was also included in the Chinese guidelines for HIV infection." 01/01/2023 - "In addition, Azvudine is the first dual-target nucleoside oral drug worldwide to simultaneously target reverse transcriptase and viral infectivity factors in the treatment of HIV infection. "
5.	Virus Diseases (Viral Diseases) 01/01/2022 - "Currently, seven 4'-modified nucleoside drug candidates such as azvudine (also known as FNC), islatravir, censavudine, balapiravir, lumicitabine, AL-335, and 4-azidothymidine have progressed into clinical stages for treating viral infections. "

Related Drugs and Biologics

1.	nirmatrelvir and ritonavir drug combination
2.	Tablets
3.	Nucleic Acids
4.	Antiviral Agents (Antivirals)
5.	Nucleosides
6.	GS-621763
7.	molnupiravir
8.	RNA-Directed DNA Polymerase (Reverse Transcriptase)
9.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
10.	Anticoagulants

Related Therapies and Procedures

1.	Therapeutics
2.	Renal Dialysis (Hemodialysis)
3.	Chinese Traditional Medicine (Traditional Chinese Medicine)
4.	Length of Stay