Suppressor of Cytokine Signaling 3 Protein

A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR. Its functions include suppression of ERYTHROPOIESIS in the fetal liver.

Also Known As:

SOCS3 Protein; Suppressor of Cytokine Signaling Protein 3; Protein, SOCS3

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Signal Transducing Adaptor Proteins
      - Suppressor of Cytokine Signaling Proteins: 116
        Suppressor of Cytokine Signaling 3 Protein: 46
  - Intracellular Signaling Peptides and Proteins: 32
    - Signal Transducing Adaptor Proteins
      - Suppressor of Cytokine Signaling Proteins: 116
        Suppressor of Cytokine Signaling 3 Protein: 46
- Peptides: 82426
  - Intracellular Signaling Peptides and Proteins: 32
    - Signal Transducing Adaptor Proteins
      - Suppressor of Cytokine Signaling Proteins: 116
        Suppressor of Cytokine Signaling 3 Protein: 46

zebrafish socs3a protein

Bio-Agent Context: Research Results