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2- (2- methyl- 1,4- dioxa- 8- azaspiro(4.5)dec- 8- yl)- 8- nitro- 6- (trifluoromethyl)- 4H- 1,3- benzothiazin- 4- one

structure in first source

Also Known As:

BTZ 043; BTZ038; BTZ043

Networked: 9 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Spiro Compounds: 2
      - 2-(2-methyl-1,4-dioxa-8-azaspiro(4.5)dec-8-yl)-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one: 9
- Sulfur Compounds: 278
  - Thiazines: 3
    - 2-(2-methyl-1,4-dioxa-8-azaspiro(4.5)dec-8-yl)-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one: 9
Polycyclic Compounds: 6
- Spiro Compounds: 2
  - 2-(2-methyl-1,4-dioxa-8-azaspiro(4.5)dec-8-yl)-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one: 9
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiazines: 3
    - 2-(2-methyl-1,4-dioxa-8-azaspiro(4.5)dec-8-yl)-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one: 9

Experts

1.	Cole, Stewart T: 4 articles (11/2018 - 09/2012)
2.	Dyson, Paul J: 3 articles (11/2018 - 09/2012)
3.	Neres, João: 3 articles (11/2018 - 09/2012)
4.	Bitter, Wilbert: 2 articles (11/2018 - 01/2014)
5.	Dhar, Neeraj: 2 articles (11/2018 - 09/2012)
6.	Makarov, Vadim: 2 articles (11/2018 - 01/2014)
7.	McKinney, John D: 2 articles (11/2018 - 09/2012)
8.	Gao, Chao: 2 articles (01/2016 - 09/2013)
9.	Wei, Yuquan: 2 articles (01/2016 - 09/2013)
10.	Ye, Ting-Hong: 2 articles (01/2016 - 09/2013)

Related Diseases

1.	Tuberculosis (Tuberculoses) 12/10/2020 - "tuberculosis burden was apparent for all BTZ cohorts, but only significant for BTZ043 at both doses. " 05/08/2014 - "Benzothiazin-4-ones (BTZs), represented by BTZ043, are a promising new class of agents for the treatment of tuberculosis and have been shown to kill Mtb in vitro, ex vivo, and in mouse models of TB. " 09/01/2013 - "tuberculosis H37Rv, 20-fold more potent than BTZ043 racemate. " 09/05/2012 - "The benzothiazinone BTZ043 is a tuberculosis drug candidate with nanomolar whole-cell activity. " 01/01/2014 - "Compared to BTZ043, PBTZ169 has improved potency, safety and efficacy in zebrafish and mouse models of tuberculosis (TB). "
2.	Infections 01/01/2016 - "Furthermore, benzothiazinethione showed superb in vivo antitubercular efficacy in an acute Mtb infection mouse model, significantly better than that of BTZ043. "

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