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TAT-BH4 peptide

synthetic peptide derived from Bcl-xL and HIV-1 TAT; improves survival in lethal total body irradiation; amino acid sequence in first source

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - TAT-BH4 peptide: 2

Experts

1.	Bullok, Kristin: 1 article (05/2006)
2.	Bähr, Mathias: 1 article (05/2006)
3.	Chang, Katherine C: 1 article (05/2006)
4.	Cobb, J Perren: 1 article (05/2006)
5.	Coopersmith, Craig M: 1 article (05/2006)
6.	Davis, Christopher G: 1 article (05/2006)
7.	Dietz, Gunnar P H: 1 article (05/2006)
8.	Dunne, Jeffrey C: 1 article (05/2006)
9.	Hotchkiss, Richard S: 1 article (05/2006)
10.	Karl, Irene E: 1 article (05/2006)

Related Diseases

1.	Sepsis (Septicemia) 05/01/2006 - "In the present study, we investigated the effects of sepsis-induced apoptosis in Bcl-x(L) transgenic mice and in wild-type mice treated with an antiapoptotic TAT-Bcl-x(L) fusion protein and TAT-BH4 peptide. "
2.	Massive Hepatic Necrosis 11/20/2003 - "Intraperitoneal injection of TAT-BH4 peptide greatly inhibited X-ray-induced apoptosis in the small intestine of mice and partially suppressed Fas-induced fulminant hepatitis. "
3.	Mitochondrial Diseases (Mitochondrial Disease) 11/20/2003 - "These findings demonstrate that TAT-BH4 peptide exerts anti-apoptotic activity both in vivo and ex vivo, and imply that it may be a useful therapeutic agent for diseases involving mitochondrial dysfunction and apoptosis."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)

Related Therapies and Procedures

1.	Intraperitoneal Injections