|1.||Wong, Donald: 6 articles (09/2014 - 01/2008)|
|2.||Korz, Walter: 3 articles (01/2014 - 01/2008)|
|3.||Huang, Eugene H: 2 articles (04/2010 - 08/2009)|
|4.||Singh, Balraj: 2 articles (04/2010 - 08/2009)|
|5.||Lucci, Anthony: 2 articles (04/2010 - 08/2009)|
|6.||Cook, Kendra R: 2 articles (04/2010 - 08/2009)|
|7.||Cristofanilli, Massimo: 2 articles (04/2010 - 08/2009)|
|8.||Shankowsky, Heather A: 1 article (09/2014)|
|9.||Iwashina, Takashi: 1 article (09/2014)|
|10.||Ding, Jie: 1 article (09/2014)|
09/15/2009 - "Further studies of the novel CTCE-9908 compound in prostate and other solid tumor inhibition are warranted. "
01/01/2014 - "These data suggest that CXCR4 inhibition by CTCE-9908 decreases the invasion potential in vitro, which then translated to a reduction of tumor spread with associated reduction in angiogenesis. "
06/15/2013 - "Treatment with CTCE-9908 in the orthotopic esophageal model leads to a reduction of metastatic spread and primary tumor growth. "
07/01/2011 - "We found that increasing doses of CTCE-9908 alone slowed the rate of tumor growth, with a 45% inhibition of primary tumor growth at 3.5 weeks of treatment with 50 mg/kg of CTCE-9908 (p = 0.005). "
09/15/2009 - "Effects of CXCR4 antagonist CTCE-9908 on prostate tumor growth."
|2.||Neoplasm Metastasis (Metastasis)
04/01/2010 - "However, CTCE-9908 as a single therapy inhibited organ-specific metastasis to leg (P < 0.05 by chi-squared test and by two-sample t-test)."
08/01/2009 - "Treatment with CTCE-9908 also significantly inhibited the rate of metastases compared with the control group. "
03/01/2009 - "However, CTCE-9908 did decrease metastatic burden (i.e., size of metastases) in all organs examined (lungs, bone, heart, liver, kidneys, pancreas and spleen). "
03/01/2009 - "Somewhat surprisingly, CTCE-9908 treatment did not decrease incidence of metastasis as hypothesized. "
03/01/2009 - "We hypothesized that treatment with a CXCR4 antagonist, CTCE-9908, would decrease incidence of bone and lung metastasis. "
|3.||Prostatic Neoplasms (Prostate Cancer)
01/01/2014 - "Hence, CTCE-9908 may prove to be an efficacious novel agent to prevent and treat the spread of metastatic prostate cancer."
01/01/2014 - "We used a panel of in vitro assays utilizing human prostate cancer cell lines and an in vivo orthotopic prostate cancer model to assess the anti-tumoral activity of CTCE-9908. "
01/01/2014 - "Herein, we tested the efficacy of CTCE-9908 in inhibiting prostate cancer cell growth, invasion, and metastasis. "
06/01/2010 - "This conference report highlights selected presentations on the development of the third-generation camptothecin analog TH-1320 (Threshold Pharmaceuticals Inc), the silencing of the androgen receptor in prostate cancer by the novel locked nucleic acid-based antisense oligonucleotide EZN-4176 (Enzon Pharmaceuticals Inc/Santaris Pharma A/S), the inhibition of PC-3 cell invasiveness and metastasis by the CXCR4 antagonist CTCE-9908 (British Canadian BioSciences Corp), the antitumor efficacy of the CDH3 mAb PPMX-2017 (Perseus Proteomics Inc), and an anti-IL-6 mAb (MedImmune LLC) that suppresses tumor growth in vivo."
|4.||Breast Neoplasms (Breast Cancer)
03/01/2009 - "Inhibition of CXCR4 by CTCE-9908 inhibits breast cancer metastasis to lung and bone."
07/01/2011 - "To determine the efficacy of targeting CXCR4 on primary tumor growth and metastasis, we used a peptide inhibitor of CXCR4, CTCE-9908, that was administered in a clinically relevant approach using a transgenic breast cancer mouse model. "
08/01/2009 - "Treatment with the CXCR4 antagonist CTCE-9908 significantly reduced metastasis as well as primary tumor growth in mouse models of breast cancer."
08/01/2009 - "A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer."
07/01/2011 - "In combination with docetaxel or an anti-angiogenic agent, the anti-tumor and anti-metastatic effects of CTCE-9908 were markedly enhanced, suggesting potentially new effective combinatorial therapeutic strategies in the treatment of breast cancer, which include targeting the SDF-1/CXCR4 ligand/receptor pair."
|5.||Osteosarcoma (Osteogenic Sarcoma)
01/01/2008 - "Following tail vein injection of osteosarcoma cells, mice that were treated with CTCE-9908 had a 50% reduction in the number of gross metastatic lung nodules and a marked decrease in micro-metastatic disease. "
01/01/2008 - "Treatment of osteosarcoma cells in vitro with CTCE-9908 led to the following changes: decreased adhesion, decreased migration, decreased invasion, and decreased growth rate. "
|1.||Androgen Receptors (Androgen Receptor)
|3.||locked nucleic acid
|4.||Intercellular Signaling Peptides and Proteins (Growth Factors)
|7.||enhanced green fluorescent protein
|1.||Heterologous Transplantation (Xenotransplantation)