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asparanin A

has antineoplastic activity; isolated from Asparagus officinalis; structure in first source

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Saponins: 2867
    - asparanin A: 5

Experts

1.	Thakur, Kiran: 3 articles (04/2021 - 01/2020)
2.	Wei, Zhao-Jun: 3 articles (04/2021 - 01/2020)
3.	Zhang, Fan: 3 articles (04/2021 - 01/2020)
4.	Zhang, Jian-Guo: 3 articles (04/2021 - 01/2020)
5.	Zhang, Yuan-Yuan: 3 articles (04/2021 - 01/2020)
6.	Han, Jinzhi: 2 articles (04/2021 - 01/2021)
7.	Ma, Run-Hui: 2 articles (01/2021 - 01/2020)
8.	Cespedes-Acuña, Carlos L: 1 article (04/2021)
9.	Ni, Zhi-Jing: 1 article (04/2021)
10.	Ye, Lei: 1 article (04/2021)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 04/17/2009 - "In this study, we show that asparanin A induces G(2)/M phase arrest and apoptosis in human hepatocellular carcinoma HepG2 cells. " 04/17/2009 - "These data indicate that asparanin A shows promise as a preventive and/or therapeutic agent against human hepatoma." 04/17/2009 - "Asparanin A induces G(2)/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells."
2.	Endometrial Neoplasms (Endometrial Cancer) 08/01/2023 - "Asparanin A exerts cytotoxicity on human endometrial cancer Ishikawa cells via regulating miR-6236-p5_4 expression." 04/01/2021 - "Asparanin A inhibits cell migration and invasion in human endometrial cancer via Ras/ERK/MAPK pathway." 01/21/2021 - "Multi-omics reveals the anticancer mechanism of asparagus saponin-asparanin A on endometrial cancer Ishikawa cells." 01/08/2020 - "Asparanin A (AA), a steroidal saponin from Asparagus officinalis L., has anticancer activity: however, its detailed molecular mechanisms in endometrial cancer (EC) have not been studied so far. " 01/21/2021 - "Due to the lack of data on the functional importance of mRNAs and miRNAs in plant-derived asparanin A (AA) induced cancer cells, the underlying mechanisms of AA on endometrial cancer (EC) Ishikawa cells were investigated using mRNA-seq and miRNA-seq, qRT-PCR, western blot, and immunohistochemistry. "
3.	Neoplasms (Cancer) 01/21/2021 - "Due to the lack of data on the functional importance of mRNAs and miRNAs in plant-derived asparanin A (AA) induced cancer cells, the underlying mechanisms of AA on endometrial cancer (EC) Ishikawa cells were investigated using mRNA-seq and miRNA-seq, qRT-PCR, western blot, and immunohistochemistry. "

Related Drugs and Biologics

1.	Saponins
2.	MicroRNAs (MicroRNA)
3.	Messenger RNA (mRNA)