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pyroglutamyl- (2- propyl)histidyl- prolinamide

structure in first source

Also Known As:

NP 647; NP-647; NP647 cpd; pGlu-(2-propyl)His-ProNH2

Networked: 2 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Peptide Hormones: 1347
    - Hypothalamic Hormones: 68
      - Pituitary Hormone-Releasing Hormones: 39
        Thyrotropin-Releasing Hormone: 1449
        pyroglutamyl-(2-propyl)histidyl-prolinamide: 2
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Thyrotropin-Releasing Hormone: 1449
        pyroglutamyl-(2-propyl)histidyl-prolinamide: 2
      - Hypothalamic Hormones: 68
        Pituitary Hormone-Releasing Hormones: 39
        Thyrotropin-Releasing Hormone: 1449
        pyroglutamyl-(2-propyl)histidyl-prolinamide: 2
- Peptides: 82426

Experts

1.	Jain, Rahul: 2 articles (06/2011 - 01/2009)
2.	Meena, Chhuttan Lal: 2 articles (06/2011 - 01/2009)
3.	Rajput, Satyendra Kumar: 2 articles (06/2011 - 01/2009)
4.	Kumar, Vivek: 1 article (06/2011)
5.	Pant, Aditya Bhushan: 1 article (06/2011)
6.	Sharma, Shyam Sunder: 1 article (06/2011)
7.	Siddiqui, Maqsood Ahmad: 1 article (06/2011)
8.	Kaur, Navneet: 1 article (01/2009)
9.	Krishnamoorthy, Srinivasan: 1 article (01/2009)
10.	Monga, Vikramdeep: 1 article (01/2009)

Related Diseases

1.	Ischemia 06/01/2011 - "In in vivo studies, NP-647 treatment showed protection of hippocampal (CA1) neuronal damage in transient global ischemia in mice and subsequent improvement in memory retention was observed using passive avoidance retention test. " 06/01/2011 - "In the present study, the newly synthesized TRH analog (L-pGlu-(2-propyl)-L-His-l-ProNH(2); NP-647) was evaluated for its effects in in vitro (oxygen glucose deprivation (OGD)-, glutamate- and H(2)O(2)-induced injury in PC-12 cells) and in vivo (transient global ischemia) models of cerebral ischemic injury. "
2.	Epilepsy (Aura) 01/01/2009 - "This study demonstrates that NP-647 has potential antiepileptic activity devoid of undesirable effects and, thus, can be exploited for the prevention and treatment of epilepsy."
3.	Seizures (Absence Seizure) 01/01/2009 - "However, NP-647 did not significantly affect theophylline-induced seizures. "
4.	Inflammation (Inflammations) 06/01/2011 - "These results suggest potential of NP-647 in the treatment of cerebral ischemia and its neuroprotective effect may be attributed to reduction of excitotoxicity, oxidative stress and inflammation."
5.	Brain Ischemia (Cerebral Ischemia) 06/01/2011 - "These results suggest potential of NP-647 in the treatment of cerebral ischemia and its neuroprotective effect may be attributed to reduction of excitotoxicity, oxidative stress and inflammation."

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5.	Ac- Nal(1)- Cpa(2)- Pal(3,6)- Arg(5)- Ala(10)- LHRH
6.	Neuroprotective Agents
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