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ALX 1393

a GlyT2 inhibitor
Also Known As:
ALX-1393; ALX1393
Networked: 9 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Haranishi, Yasunori: 2 articles (03/2015 - 02/2010)
2. Terada, Tadanori: 2 articles (03/2015 - 02/2010)
3. Sata, Takeyoshi: 2 articles (03/2015 - 02/2010)
4. Hara, Koji: 2 articles (03/2015 - 02/2010)
5. Dohi, Toshihiro: 2 articles (10/2014 - 08/2008)
6. Motoyama, Naoyo: 2 articles (10/2014 - 08/2008)
7. Kitayama, Tomoya: 2 articles (10/2014 - 08/2008)
8. Morita, Katsuya: 2 articles (10/2014 - 08/2008)
9. Hermanns, Henning: 2 articles (07/2014 - 11/2008)
10. Werdehausen, Robert: 2 articles (07/2014 - 11/2008)

Related Diseases

1. Pain (Aches)
2. Neoplasms (Cancer)
3. Neuralgia (Stump Neuralgia)
03/01/2015 - "The present study examined the antinociceptive effect of intracerebroventricular (i.c.v.) administration of the selective GlyT2 inhibitor ALX1393 on inflammatory and neuropathic pain in experimental models. "
07/01/2014 - "In the chronic constriction injury model of neuropathic pain, male Wistar rats received specific GlyT1 and GlyT2 inhibitors (ALX5407 and ALX1393; Sigma-Aldrich, St. Louis, MO) or vehicle for 14 days via subcutaneous osmotic infusion pumps (n = 6). "
03/01/2015 - "Antinociceptive effect of intracerebroventricular administration of glycine transporter-2 inhibitor ALX1393 in rat models of inflammatory and neuropathic pain."
11/21/2008 - "In the present study, we investigated the effects of the spinally applied glycine transporter inhibitors ALX 5407 (GlyT1) and ALX 1393 (GlyT2) on nociceptive behavior in the chronic constriction injury model of neuropathic pain in male Wistar rats. "
08/01/2008 - "In this study, we demonstrated that i.v. or intrathecal administration of GlyT1 inhibitors, cis-N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl methyl)amino methylcarboxylic acid (ORG25935) or sarcosine, and GlyT2 inhibitors, 4-benzyloxy-3,5-dimethoxy-N-[1-(dimethylaminocyclopently)-methyl]benzamide (ORG25543) and (O-[(2-benzyloxyphenyl-3-fluorophenyl)methyl]-L-serine) (ALX1393), or knockdown of spinal GlyTs by small interfering RNA of GlyTs mRNA produced a profound antiallodynia effect in a partial peripheral nerve ligation model and other neuropathic pain models in mice. "
4. Hyperalgesia
5. Respiratory Insufficiency (Respiratory Failure)

Related Drugs and Biologics

1. N- methyl- N- (6- methoxy- 1- phenyl- 1,2,3,4- tetrahydronaphthalen- 2- ylmethyl)aminomethylcarboxylic acid
2. Sarcosine (Methylglycine)
3. Small Interfering RNA (siRNA)
4. Glycine Plasma Membrane Transport Proteins
5. Serine (L-Serine)
6. Messenger RNA (mRNA)
7. 4- benzyloxy- 3,5- dimethoxy- N- (1- (dimethylaminocyclopently)methyl)benzamide
8. (R)- (N- (3- (4'- fluorophenyl)- 3- (4'- phenylphenoxy)propyl))sarcosine
9. benzamide
10. Glycine (Aminoacetic Acid)

Related Therapies and Procedures

1. Transplantation (Transplant Recipients)
2. Oral Administration
3. Ligation
4. Infusion Pumps (Infusion Pump)