2- (6- (2- carboxyvinyl)- 2,3- dihydroxyphenyl)- 3- (3,4- dihydroxyphenyl)acrylic acid

03/31/2009 - "The present study was conducted to evaluate whether SMND-309 has a protective effect on permanent focal cerebral ischemia in rats. "
08/15/2013 - "The present study aimed to investigate the mechanisms associated with the protective activities of SMND-309 in a cerebral ischemia and reperfusion injury rat model. "
08/01/2009 - "The present study was conducted to investigate whether SMND-309 has a protective effect on brain injury after focal cerebral ischemia, and if it did so, to investigate its effects on brain mitochondria. "
08/01/2009 - "All of these findings indicate that SMND-309 exerted potent neuroprotective effects in the model of permanent cerebral ischemia, contributed to its protections on brain mitochondrial structure and function."
08/01/2009 - "Protections of SMND-309, a novel derivate of salvianolic acid B, on brain mitochondria contribute to injury amelioration in cerebral ischemia rats."

04/01/2010 - "The present study was designed to investigate the cardioprotective potential of SMND-309 and to elucidate the possible mechanisms on the basis of biochemical, histopathological and immunohistochemical studies in a rat model of acute myocardial infarction induced by permanent ligation of the left coronary artery. "
04/01/2010 - "Cardioprotective effect of SMND-309, a novel derivate of salvianolic acid B on acute myocardial infarction in rats."
04/01/2010 - "Moreover, SMND-309 exhibits significantly higher potency compared to salvianolic acid B at the same mg/kg but not the same mol/kg. These findings indicate that SMND-309 has a protective potential against myocardial infarction injury and the protective effects may be due to its scavenging lipid peroxidation products, increasing endogenous antioxidant defence enzymes and attenuating cardiocyte apoptosis."

01/01/2022 - "An active component of Salvia miltiorrhiza, SMND-309, dramatically alleviated these injuries and improved cognitive deficits of CIH mice."

03/31/2009 - "SMND-309, a novel derivate of salvianolic acid B, ameliorates cerebral infarction in rats: characterization and role."

08/15/2013 - "The present study aimed to investigate the mechanisms associated with the protective activities of SMND-309 in a cerebral ischemia and reperfusion injury rat model. "
08/15/2013 - "Our results suggest that SMND-309 provides significant neuroprotective effects against cerebral ischemia and reperfusion injury. "
08/15/2013 - "SMND-309, a novel derivative of salvianolic acid B, protects rat brains ischemia and reperfusion injury by targeting the JAK2/STAT3 pathway."
08/15/2013 - "SMND-309 mitigated the effects of ischemia and reperfusion injury on brain by decreasing the infract volume, improving neurological function, increasing the survival of neurons and promoting angiogenesis by increasing the levels of erythropoietin (EPO), erythropoietin receptor (EPOR), phosphorylated JAK2 (P-JAK2), phosphorylated STAT3 (P-STAT3), VEGF and VEGF receptor 2 (Flk-1) in the brain. "