(5,10,15,20- tetrakis(N- (benzyl- 4'- carboxylate)- 2- pyridinium)- 21H,23H- porphine)iron(III)

a peroxynitrite decomposition catalyst; structure in first source

Also Known As:

INO 4885; INO-4885; INO4885

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Coordination Complexes: 576
  - Metalloporphyrins: 178
    - (5,10,15,20-tetrakis(N-(benzyl-4'-carboxylate)-2-pyridinium)-21H,23H-porphine)iron(III): 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrroles: 369
      - Tetrapyrroles: 70
        Porphyrins: 3316
        Metalloporphyrins: 178
        (5,10,15,20-tetrakis(N-(benzyl-4'-carboxylate)-2-pyridinium)-21H,23H-porphine)iron(III): 2
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - Tetrapyrroles: 70
      - Porphyrins: 3316
        Metalloporphyrins: 178
        (5,10,15,20-tetrakis(N-(benzyl-4'-carboxylate)-2-pyridinium)-21H,23H-porphine)iron(III): 2
Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Tetrapyrroles: 70
    - Porphyrins: 3316
      - Metalloporphyrins: 178
        (5,10,15,20-tetrakis(N-(benzyl-4'-carboxylate)-2-pyridinium)-21H,23H-porphine)iron(III): 2
Biological Factors: 2472
- Biological Pigments: 1
  - Porphyrins: 3316
    - Metalloporphyrins: 178
      - (5,10,15,20-tetrakis(N-(benzyl-4'-carboxylate)-2-pyridinium)-21H,23H-porphine)iron(III): 2

Experts

1.	Connelly, Rhykka: 1 article (02/2011)
2.	Cox, Robert A: 1 article (02/2011)
3.	Enkhbaatar, Perenlei: 1 article (02/2011)
4.	Esechie, Aimalohi: 1 article (02/2011)
5.	Hamahata, Atsumori: 1 article (02/2011)
6.	Herndon, David N: 1 article (02/2011)
7.	Horvath, Eszter: 1 article (02/2011)
8.	Lange, Matthias: 1 article (02/2011)
9.	Nakano, Yoshimitsu: 1 article (02/2011)
10.	Szabo, Csaba: 1 article (02/2011)

Related Diseases

1.	Myocardial Ischemia (Ischemic Heart Diseases) 03/01/2009 - "The present study determined whether INO-4885 [5,10,15,20-tetra[N-(benzyl-4'-carboxylate)-2-pyridinium]-21H,23H-porphine iron(III) chloride], a new peroxynitrite decomposition catalyst, may provide cellular protection and protect heart from myocardial ischemia/reperfusion injury. "
2.	Reperfusion Injury 03/01/2009 - "INO-4885 [5,10,15,20-tetra[N-(benzyl-4'-carboxylate)-2-pyridinium]-21H,23H-porphine iron(III) chloride], a peroxynitrite decomposition catalyst, protects the heart against reperfusion injury in mice." 03/01/2009 - "The present study determined whether INO-4885 [5,10,15,20-tetra[N-(benzyl-4'-carboxylate)-2-pyridinium]-21H,23H-porphine iron(III) chloride], a new peroxynitrite decomposition catalyst, may provide cellular protection and protect heart from myocardial ischemia/reperfusion injury. "
3.	Lung Injury 02/01/2011 - "Here we tested the effect of the ONOO(-) decomposition catalyst INO-4885 on the development of lung injury in chronically instrumented sheep with combined burn and smoke inhalation injury. "
4.	Myocardial Reperfusion Injury 03/01/2009 - "Taken together, our data demonstrated that INO-4885 is a cardioprotective molecule that attenuates myocardial reperfusion injury by facilitating peroxynitrite decomposition and inhibiting NADPH oxidase-derived O2(.-) production."
5.	Smoke Inhalation Injury 02/01/2011 - "Here we tested the effect of the ONOO(-) decomposition catalyst INO-4885 on the development of lung injury in chronically instrumented sheep with combined burn and smoke inhalation injury. "

Related Drugs and Biologics

1.	Peroxynitrous Acid (Peroxynitrite)
2.	Iron
3.	Chlorides
4.	porphine (porphin)
5.	Caspase 3 (Caspase-3)
6.	NADPH Oxidases (NAD(P)H oxidase)
7.	Smoke
8.	Proteins (Proteins, Gene)
9.	salicylhydroxamic acid (SHAM)
10.	3-nitrotyrosine