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N- fluoroacetyl- N- (2,5- dimethoxybenzyl)- 2- phenoxyaniline

a peripheral benzodiazepine receptor PET ligand; structure in first source

Also Known As:

(18F)N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline; 18F-PBR06; N-fluoroacetyl-2MeOBzPhOA

Networked: 5 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - Anilides: 22
      - Acetanilides: 7
        N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline: 5
- Amides: 2428
  - Anilides: 22
    - Acetanilides: 7
      - N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline: 5

Experts

1.	Singhal, Tarun: 2 articles (02/2021 - 09/2018)
2.	Weiner, Howard L: 2 articles (02/2021 - 09/2018)
3.	Carter, Kelsey: 1 article (02/2021)
4.	Cicero, Steven: 1 article (02/2021)
5.	Ficke, John: 1 article (02/2021)
6.	Rissanen, Eero: 1 article (02/2021)
7.	Cheng, Dengfeng: 1 article (04/2019)
8.	Fu, Zhequan: 1 article (04/2019)
9.	Hu, Yan: 1 article (04/2019)
10.	Lin, Qingyu: 1 article (04/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2011 - "These preclinical studies illustrate that 18F-PBR06 is a promising tracer for visualization of TSPO-expressing tumors. " 01/01/2011 - "18F-PBR06 was found to preferentially accumulate in tumors, with modest uptake in the contralateral brain, facilitating excellent contrast between tumor and adjacent tissue. " 01/01/2011 - "Specific tumor cell binding of PBR06 was evaluated by radioligand displacement of 3H-PK 11195 with PBR06 in vitro and by displacement of 18F-PBR06 with excess PBR06 in vivo. " 01/01/2011 - "These data suggest the potential of 18F-PBR06 to elucidate the role of TSPO in oncology, as well as its potential development as a cancer imaging biomarker." 01/01/2011 - "The accumulation of 18F-PBR06 in tumor tissues and adjacent brain agreed with the ex vivo assay of TSPO protein levels by Western blotting and quantitative immunohistochemistry. "
2.	Glioma (Gliomas) 01/01/2011 - "Glioma-bearing rats were imaged with 18F-PBR06 in a small-animal PET system. " 01/01/2011 - "Importantly, the close correlation between 18F-PBR06 uptake and TSPO expression in tumors and normal tissues, coupled with the high degree of displaceable binding from both tumors and the normal brain, represents a significant improvement over other TSPO imaging ligands previously evaluated in glioma. "
3.	Atherosclerotic Plaque (Atheroma) 04/01/2019 - "18F-PBR06 PET/CT imaging for evaluating atherosclerotic plaques linked to macrophage infiltration."
4.	Chronic Progressive Multiple Sclerosis 02/01/2021 - "Widespread Glial Activation in Primary Progressive Multiple Sclerosis Revealed by 18F-PBR06 PET: A Clinically Feasible, Individualized Approach." 02/01/2021 - "A 64-year-old man with primary progressive multiple sclerosis (Expanded Disability Status Scale 3.5) underwent PET using 18F-PBR06, a second-generation 18-kDa translocator protein ligand targeting activated brain microglia and astrocytes. "
5.	Multiple Sclerosis 09/01/2018 - "18F-PBR06 Versus 11C-PBR28 PET for Assessing White Matter Translocator Protein Binding in Multiple Sclerosis."

Related Drugs and Biologics

1.	Ligands
2.	Proteins (Proteins, Gene)
3.	Biomarkers (Surrogate Marker)
4.	(methyl- (11)C)N- acetyl- N- (2- methoxybenzyl)- 2- phenoxy- 5- pyridinamine