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2-aminoethyl diphenylborinate

a synthetic potent activator of transient receptor potential cation channels 3 and 4; do not confuse with 2-APB compound

Also Known As:

2-APB cpd

Networked: 9 relevant articles (1 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Boron Compounds: 91
  - 2-aminoethyl diphenylborinate: 9
Organic Chemicals: 133
- Boron Compounds: 91
  - 2-aminoethyl diphenylborinate: 9

Experts

1.	Mikoshiba, Katsuhiko: 2 articles (01/2018 - 05/2015)
2.	Hsieh, Yi-Chun: 1 article (08/2021)
3.	Hsu, Wen-Li: 1 article (08/2021)
4.	Wu, Ching-Ying: 1 article (08/2021)
5.	Yoshioka, Tohru: 1 article (08/2021)
6.	Yu, Hsin-Su: 1 article (08/2021)
7.	Dabirmanesh, Bahareh: 1 article (01/2021)
8.	Fathollahi, Yaghoub: 1 article (01/2021)
9.	Khajeh, Khosro: 1 article (01/2021)
10.	Khorsand, Babak: 1 article (01/2021)

Related Diseases

1.	Noise-Induced Hearing Loss (Acoustic Trauma) 04/01/2015 - "The Potential Protective Effects of 2-aminoethyl Diphenylborinate against Inner Ear Acoustic Trauma: Experimental Study Using Transmission and Scanning Electron Microscopy." 04/01/2015 - "In this prospective experimental study, we investigated the preventive effects of 2-aminoethyl diphenylborinate (2-APB) in rats exposed to acoustic trauma (AT). "
2.	Subarachnoid Hemorrhage (Aneurysmal Subarachnoid Hemorrhage) 07/01/2019 - "Effects of 2-Aminoethyl Diphenylborinate, a Modulator of Transient Receptor Potential and Orai Channels in Subarachnoid Hemorrhage: An Experimental Study."
3.	Ischemia 04/01/2014 - "To investigate the protective effect of 2-aminoethyl diphenylborinate (2-APB) against ischemia-reperfusion (I/R) injury in the rat kidney by an experimental study. "
4.	Malaria 05/01/2015 - "Simultaneous administration of 2-aminoethyl diphenylborinate and chloroquine reverses chloroquine resistance in malaria parasites." 01/01/2018 - "The melatonin-induced cytosolic Ca2+ ([Ca2+]cyt) increase and malaria cell cycle can be blocked by the IP3 receptor blocker 2-aminoethyl diphenylborinate (2-APB). "
5.	Breast Neoplasms (Breast Cancer) 08/01/2015 - "By testing analogs of 2-aminoethyl diphenylborinate (2-APB), a well known, though not so selective effector of the SOCE, we identified methoxy diethylborinate (MDEB), a molecule able to potentiate the SOCE in three leukocyte and two breast cancer cell lines by increasing the Ca(2+) influx amplitude. " 08/05/2020 - "Synthesis and Pharmacological Characterization of 2-Aminoethyl Diphenylborinate (2-APB) Derivatives for Inhibition of Store-Operated Calcium Entry (SOCE) in MDA-MB-231 Breast Cancer Cells."

Related Drugs and Biologics

1.	Calcium
2.	Inositol 1,4,5-Trisphosphate Receptors (Inositol Triphosphate Receptor)
3.	Transient Receptor Potential Channels
4.	Melatonin
5.	Chloroquine (Aralen)
6.	Bleomycin (Blenoxane)