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Mitochondrial encephalopathy

Mitochondrial myopathy encephalopathy lactic acidosis and strokelike episodes
Networked: 169 relevant articles (3 outcomes, 9 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Stroke (Strokes)
2. Lactic Acidosis
3. MELAS Syndrome (Syndrome, MELAS)
4. Coenzyme Q10 Deficiency
5. Mitochondrial Diseases (Mitochondrial Disease)

Experts

1. López, Luis C: 4 articles (04/2019 - 07/2014)
2. Zeviani, Massimo: 4 articles (11/2017 - 01/2006)
3. Finsterer, Josef: 3 articles (02/2022 - 10/2021)
4. Ji, Kunqian: 3 articles (01/2022 - 03/2014)
5. Yan, Chuanzhu: 3 articles (01/2022 - 03/2014)
6. Acuña-Castroviejo, Darío: 3 articles (04/2019 - 07/2014)
7. Barriocanal-Casado, Eliana: 3 articles (04/2019 - 01/2016)
8. Escames, Germaine: 3 articles (04/2019 - 07/2014)
9. Hidalgo-Gutiérrez, Agustín: 3 articles (04/2019 - 01/2016)
10. Bertini, Enrico: 3 articles (01/2018 - 03/2014)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Mitochondrial encephalopathy:
1. TaurineFDA Link
2. Sympathomimetics (Sympathomimetic Amines)IBA
3. AminesIBA
4. ubiquinol-10IBA
5. Mitochondrial DNA (mtDNA)IBA
6. Arginine (L-Arginine)FDA Link
7. Proteins (Proteins, Gene)FDA Link
12/15/2005 - "Interestingly, 14-3-3 CSF protein was detected at the beginning of mitochondrial encephalopathy without new MRI abnormalities, suggesting that it is a sensitive brain marker. "
01/01/2021 - "Mutations in these Fe-S scaffold and trafficking proteins can cause diseases such as multiple mitochondrial dysfunctions syndrome (MMDS), sideroblastic anemia, and mitochondrial encephalopathy. "
10/01/2021 - "In a 56-year-old male with mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) manifesting with recurrent stroke-like episodes, seizures, cognitive impairment, ataxia, psychiatric abnormalities, bilateral visual impairment, bilateral hypoacusis, pre-diabetes, hyperlipidemia, myopathy, and lactic acidosis, an asymptomatic, pre-epiglottic cyst with 1 cm in diameter and protein-rich content in the right tongue root was accidentally detected on ultrasound and confirmed by MRI at the age of 50 years. "
04/01/2004 - "We used C(2)C(12) cells depleted of mtDNA (rho(-) cells) and fibroblasts from a mitochondrial encephalopathy, lactic acidosis, and strokelike episodes (MELAS) patient to examine adaptations of the protein import machinery and transcription factors involved in mitochondrial biogenesis. "
10/01/2018 - "Herein, we have investigated the protein signature of metabolism and of the antioxidant response in muscle biopsies of clinically and genetically diagnosed patients with Progressive External Ophthalmoplegia due to single large-scale (PEO-sD) or multiple (PEO-mD) deletions of mtDNA and Mitochondrial Encephalopathy Lactic Acidosis and Stroke-like episode (MELAS) syndrome, and healthy donors. "
8. Biomarkers (Surrogate Marker)IBA
9. ubiquinone 9IBA
10. UbiquinoneIBA

Therapies and Procedures

1. Therapeutics
2. Cochlear Implants (Cochlear Implant)
3. Cochlear Implantation
4. Ketogenic Diet
5. Heart Transplantation (Grafting, Heart)