Double cortex

Networked: 13 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Nervous System Diseases: 14178
- Nervous System Malformations: 35
  - Malformations of Cortical Development: 376
    - Group II Malformations of Cortical Development: 62
      - Lissencephaly: 236
        Classical Lissencephalies and Subcortical Band Heterotopias: 126
        Double cortex: 13
      - Classical Lissencephalies and Subcortical Band Heterotopias: 126
        Double cortex: 13
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Congenital Abnormalities: 25723
  - Nervous System Malformations: 35
    - Malformations of Cortical Development: 376
      - Group II Malformations of Cortical Development: 62
        Lissencephaly: 236
        Classical Lissencephalies and Subcortical Band Heterotopias: 126
        Double cortex: 13
        Classical Lissencephalies and Subcortical Band Heterotopias: 126
        Double cortex: 13
- Inborn Genetic Diseases: 11939
  - X-Linked Genetic Diseases: 42
    - X-Linked Mental Retardation: 272
      - Classical Lissencephalies and Subcortical Band Heterotopias: 126
        Double cortex: 13

Related Diseases

1.	Classical Lissencephalies and Subcortical Band Heterotopias
2.	Epilepsy (Aura)
3.	Neuroaxonal Dystrophies (Neuroaxonal Dystrophy, Late Infantile)
4.	Mitochondrial Encephalomyopathies (Mitochondrial Encephalomyopathy)
5.	Seizures (Absence Seizure)

Experts

1.	Atmaca, Murat Mert: 1 article (12/2017)
2.	Baykan, Betul: 1 article (12/2017)
3.	Bebek, Nerses: 1 article (12/2017)
4.	Erdag, Ece: 1 article (12/2017)
5.	Gurses, Candan: 1 article (12/2017)
6.	Tuzun, Erdem: 1 article (12/2017)
7.	Konno, Daijiro: 1 article (09/2015)
8.	Mandai, Kenji: 1 article (09/2015)
9.	Maruo, Tomohiko: 1 article (09/2015)
10.	Matsuzaki, Fumio: 1 article (09/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Double cortex:

1.	IronIBA 10/01/2023 - "Reply to: "Susceptibility-Weighted Imaging Reveals Subcortical Iron Deposition in PLAN: The "Double Cortex Sign""." 10/01/2023 - "Reply to: "Susceptibility-Weighted Imaging Reveals Subcortical Iron Deposition in PLAN: The 'Double Cortex Sign'"." 01/01/2023 - "Susceptibility-Weighted Imaging Reveals Subcortical Iron Deposition in PLA2G6-associated Neurodegeneration: The "Double Cortex Sign"."
2.	afadinIBA 09/16/2015 - "Taken together, these findings indicate that afadin is required for the maintenance of the radial glial scaffold for neuronal migration and that the genetic ablation of afadin leads to the formation of double cortex. " 09/16/2015 - "Here, we report that mice with dorsal telencephalon-specific ablation of afadin gene exhibited defects similar to human double cortex, in which the heterotopic cortex was located underneath the normotopic cortex. " 09/16/2015 - "Impairment of radial glial scaffold-dependent neuronal migration and formation of double cortex by genetic ablation of afadin." 08/06/2014 - "Inactivation of afadin or CDH2 in the dorsal telencephalon leads to a phenotype resembling subcortical band heterotopia, also known as "double cortex," a brain malformation in which heterotopic gray matter is interposed between zones of white matter. "
3.	Monomeric GTP-Binding ProteinsIBA 01/01/2013 - "We recently found that genetic deletion of the small GTPase RhoA in the developing mouse cerebral cortex results in three distinct cortical malformations: a defect in the proliferation of progenitor cells during development that leads to a bigger cerebral cortex in the adult mouse, a change in the morphology of radial glial cells that results in the formation of a subcortical band heterotopia (SBH, also called Double Cortex) and an increase in the speed of migrating newborn neurons. "
4.	Brain-Derived Neurotrophic Factor (BDNF)IBA 06/01/1994 - "We studied the mRNA expression of a member of the neurotrophin family, brain-derived neurotrophic factor (BDNF), and of the two receptor transcripts, full-length trkB and truncated trkB in single intraocular cortex cerebri grafts and in double cortex cerebri grafts. "
5.	N-Methylaspartate (NMDA)IBA 12/01/2017 - "Four patients had a short epilepsy duration, while one of the NMDA-R antibody-positive patients had chronic epilepsy and double cortex finding in MRI. "
6.	TitaniumIBA 10/17/2014 - "Two titanium implants, single and double cortex crossing, are inserted in the rat tibia. "
7.	Messenger RNA (mRNA)IBA 06/01/1994 - "We studied the mRNA expression of a member of the neurotrophin family, brain-derived neurotrophic factor (BDNF), and of the two receptor transcripts, full-length trkB and truncated trkB in single intraocular cortex cerebri grafts and in double cortex cerebri grafts. "
8.	Proteins (Proteins, Gene)FDA Link 12/01/1998 - "LIS1 encodes a protein related to platelet-activating factor acetyl hydrolase that is defective in lissencephaly-1 of the Miller-Dieker type, while the double cortex malformation is related to mutations of a new gene dubbed doublecortn."
9.	Platelet Activating FactorIBA 12/01/1998 - "LIS1 encodes a protein related to platelet-activating factor acetyl hydrolase that is defective in lissencephaly-1 of the Miller-Dieker type, while the double cortex malformation is related to mutations of a new gene dubbed doublecortn."
10.	Nerve Growth Factors (Neurotrophins)IBA 06/01/1994 - "We studied the mRNA expression of a member of the neurotrophin family, brain-derived neurotrophic factor (BDNF), and of the two receptor transcripts, full-length trkB and truncated trkB in single intraocular cortex cerebri grafts and in double cortex cerebri grafts. "