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Segmental glomerulosclerosis

A pathologic finding in several renal disorders that manifest clinically as PROTEINURIA and progressive decline in renal function. Some patients develop NEPHROTIC SYNDROME (OMIM: 256300), but others may only have proteinuria in the nephrotic syndrome range. Autosomal dominant mutations in the ACTN4 gene have been identified in some cases. OMIM: 603278
Also Known As:
FSGS1; Focal sclerosis with hyalinosis; Focal segmental glomerulosclerosis 1; Glomerulosclerosis, Focal Segmental, 1
Networked: 316 relevant articles (20 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Proteinuria
2. Nephrotic Syndrome (Syndrome, Nephrotic)
3. Lipoid Nephrosis (Glomerulonephritis, Minimal Change)
4. Membranous Glomerulonephritis (Membranous Nephropathy)
5. IGA Glomerulonephritis (IGA Nephropathy)

Experts

1. Dryer, Stuart E: 7 articles (01/2022 - 05/2014)
2. Kim, Eun Young: 6 articles (01/2022 - 01/2018)
3. Audard, Vincent: 5 articles (01/2021 - 05/2012)
4. Pollak, Martin R: 5 articles (01/2014 - 12/2002)
5. Reiser, Jochen: 4 articles (10/2018 - 09/2010)
6. Barua, Moumita: 4 articles (01/2018 - 02/2013)
7. Grimbert, Philippe: 3 articles (01/2021 - 05/2012)
8. Praga, Manuel: 3 articles (01/2021 - 10/2012)
9. Amore, Alessandro: 3 articles (01/2020 - 05/2013)
10. Coppo, Rosanna: 3 articles (01/2020 - 01/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Segmental glomerulosclerosis:
1. SteroidsIBA
2. Cyclosporine (Ciclosporin)FDA LinkGeneric
3. Rituximab (Mabthera)FDA Link
4. Cyclophosphamide (Cytoxan)FDA LinkGeneric
5. LDL Lipoproteins (beta Lipoproteins)IBA
6. Angiotensin IIIBA
7. oxidized low density lipoproteinIBA
8. Doxorubicin (Adriamycin)FDA LinkGeneric
9. Puromycin AminonucleosideIBA
10. AlbuminsIBA
01/01/2009 - "The 17 children with poor outcome (c + d) had lower GFR at onset and at follow-up, higher albumin excretion at follow-up, and higher percentage of segmental glomerulosclerosis in the renal biopsy, than those with good outcome. "
08/01/1997 - "However, the presence of less-anionic albumin in urine than plasma from MCNS and focal and segmental glomerulosclerosis (FSGS) patients has been interpreted both as evidence for partial maintenance of charge selectivity and for involvement of other pathogenic mechanisms. "
03/01/1994 - "From a structural point of view, the glomeruli showed 1) an increase in size, 2) a decrease in capillary surface, 3) a diffuse thickening of the glomerular basement membrane, 4) an expansion of the mesangial matrix, and 5) an accumulation of albumin droplets in podocytes inducing 6) a dispersed focal and segmental glomerulosclerosis which, at 30 mo, affected < 2% of glomeruli. "
09/01/2017 - "Regarding morphological diagnoses, albumin was significantly lower in amyloidosis (AMY) and membranous (MGN), membranoproliferative (MPGN) or mixed glomerulonephritis (MixGN) than in minimal change disease, primary (FSGS I) or secondary (FSGS II) focal and segmental glomerulosclerosis and juvenile nephropathies (JN). "
12/01/2000 - "Patients suffering from focal and segmental glomerulosclerosis (FSGS) and in whom this disease recurs after transplantation are likely to have an active form of the disease and to have a factor(s) (such as, albuminuric factor) present in their blood that alters glomerular permeability for albumin. "

Therapies and Procedures

1. Therapeutics
2. Plasma Exchange
3. Blood Component Removal (Apheresis)
4. Kidney Transplantation
5. Transplantation