|1.||Wyse, Angela T S: 6 articles (02/2013 - 03/2003)|
|2.||Campion, Dominique: 5 articles (02/2008 - 09/2002)|
|3.||Marchitti, Satori A: 3 articles (11/2009 - 06/2007)|
|4.||Vasiliou, Vasilis: 3 articles (11/2009 - 06/2007)|
|5.||Hecketsweiler, Bernadette: 3 articles (01/2007 - 09/2002)|
|6.||Thibaut, Florence: 3 articles (01/2007 - 09/2002)|
|7.||Nadrich, Robert H: 2 articles (06/2014 - 09/2011)|
|8.||Clelland, Catherine L: 2 articles (06/2014 - 09/2011)|
|9.||Clelland, James D: 2 articles (06/2014 - 09/2011)|
|10.||Read, Laura L: 2 articles (06/2014 - 09/2011)|
01/01/2015 - "From a diagnostic viewpoint, early detection of impaired intellectual functioning and hyperprolinemia in patients with epilepsy with 22q11.2DS may be helpful in predicting the developmental timing of interictal psychosis. "
01/01/1991 - "A 9-year-old girl with type I hyperprolinemia, who also had photogenic epilepsy, was reported. "
01/01/1991 - "[A case of type I hyperprolinemia associated with photogenic epilepsy]."
02/01/2008 - "Type I hyperprolinemia and proline dehydrogenase (PRODH) mutations in four Italian children with epilepsy and mental retardation."
|2.||Schizophrenia (Dementia Praecox)
03/01/2005 - "At least 16 PRODH missense mutations have been identified in studies of type I hyperprolinemia (HPI) and schizophrenia, 10 of which are present at polymorphic frequencies. "
09/01/2011 - "Mild to moderate hyperprolinemia is a significant risk factor for schizophrenia, and may represent an intermediate phenotype in the disease. "
09/01/2011 - "Evidence for association of hyperprolinemia with schizophrenia and a measure of clinical outcome."
10/01/2007 - "Heterozygous and homozygous mutations have been identified in patients with variable hyperprolinemia and various features (patients with schizophrenia, chromosome 22q11 microdeletions and/or neurological defects). "
03/01/2005 - "Interestingly, three of the four alleles associated with or found in schizophrenia (V427M, L441P, and R453C) resulted in severe reduction of POX activity and hyperprolinemia. "
|3.||Chromosome Aberrations (Chromosome Abnormalities)
08/01/2009 - "Aside from hyperprolinemia type II these disorders usually present with therapyresistant (myoclonic) seizures in the neonatal period. "
07/01/2000 - "We report two siblings with Type I hyperprolinemia who presented with recurrent seizures. "
04/01/1987 - "The patient had a characteristic facial appearance of hyperprolinemia and suffered from convulsions after the age of 10 months. "
01/01/1987 - "The scans showed decreased metabolic rates relative both to those in the caudate nucleus and to normal control values in 3 patients whose seizures began before the age of 1, as well as in a patient with hyperprolinemia. "
05/04/2001 - "We previously identified vitamin B6 deficiency in a child presenting with seizures whose primary diagnosis was the inherited disorder hyperprolinemia type II. This is an unrecognized association, which was not explained by diet or medication. "
|5.||Psychotic Disorders (Schizoaffective Disorder)
03/30/2012 - "Moreover, an association between adulthood schizoaffective disorders and moderate hyperprolinemia has been reported. "
05/01/2005 - "Hyperprolinemia is a risk factor for schizoaffective disorder."
05/01/2005 - "We report that, taking into account a confounding effect due to valproate treatment, hyperprolinemia is a risk factor for DSM IIIR schizoaffective disorder (P=0.02, Odds ratio=4.6, 95% confidence interval 1.3-16.3). "
05/01/2005 - "Our objective was (i) to determine whether hyperprolinemia is associated with increased susceptibility for any of three psychiatric conditions (schizophrenia, schizoaffective disorder and bipolar disorder) and (ii) to establish a correlation between hyperprolinemia and PRODH genotypes. "
10/10/2013 - "Hyperprolinemia is an inherited disorder of proline metabolism and hyperprolinemic patients can present neurological manifestations, such as seizures, cognitive dysfunctions, and schizoaffective disorders. "
|3.||Proline Oxidase (Proline Dehydrogenase)
|7.||Vitamin B 6
|9.||Brain-Derived Neurotrophic Factor (BDNF)
|10.||Neurotransmitter Agents (Neurotransmitter)