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Hyperkeratosis lenticularis perstans

Also Known As:

Flegel disease; Flegel's disease; Hyperkeratosis lenticularis perstans of Flegel

Networked: 14 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Skin and Connective Tissue Diseases
- Skin Diseases: 13127
  - Keratosis: 706
    - Hyperkeratosis lenticularis perstans: 14

Related Diseases

1.	Hyperkeratosis lenticularis perstans
2.	Hyperpigmentation
3.	Epidermolytic Hyperkeratosis (Bullous Congenital Ichthyosiform Erythroderma)
4.	X-Linked Ichthyosis (Ichthyosis, X Linked)
5.	Ichthyosis Vulgaris (Dominant Ichthyosis Vulgaris)

Experts

1.	Gleghorn, Kristyna: 1 article (08/2019)
2.	Kelly, Erica: 1 article (08/2019)
3.	Riddle, Tanya: 1 article (08/2019)
4.	Subrt, Adrian: 1 article (08/2019)
5.	Frank, Jorge: 1 article (11/2008)
6.	Poblete-Gutierrez, Pamela: 1 article (11/2008)
7.	Sterneberg-Vos, Heleen: 1 article (11/2008)
8.	van Marion, Arienne M W: 1 article (11/2008)
9.	Lindsay, Ellie: 1 article (03/2005)
10.	Apaydin, R: 1 article (03/2002)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Hyperkeratosis lenticularis perstans:

1.	Fluorouracil (Carac)FDA LinkGeneric 01/01/1987 - "We report a case of hyperkeratosis lenticularis perstans from our institution that was treated successfully with topical 5-fluorouracil." 01/01/1980 - "Treatment of hyperkeratosis lenticularis perstans (Flegel) with topical fluorouracil." 01/01/2001 - "Here, we report on a patient with Flegel's disease who did respond to topical 5-fluorouracil, whereas topical vitamin D(3) synthetics were ineffective."
2.	Cholecalciferol (Vitamin D3)FDA Link 01/01/2000 - "[Hyperkeratosis lenticularis perstans (Flegel's disease) - a complex disorder of epidermal differentiation with good response to a synthetic vitamin D3 derivate]." 01/01/2001 - "Here, we report on a patient with Flegel's disease who did respond to topical 5-fluorouracil, whereas topical vitamin D(3) synthetics were ineffective."
3.	calcipotriene (calcipotriol)FDA LinkGeneric 03/01/2002 - "Flegel's disease: treatment with topical calcipotriol." 01/01/2001 - "Hyperkeratosis lenticularis perstans (Flegel's disease)--lack of response to treatment with tacalcitol and calcipotriol."
4.	ZincIBA 03/01/2005 - "Zinc paste bandages and the treatment of Flegel's disease."
5.	Sulfides (Thioethers)IBA 01/01/1981 - "[Dynamic changes of sulfide and disulfide groups in the abnormal keratinization process of hyperkeratosis lenticularis perstans (author's transl)]."
6.	RetinoidsIBA 01/01/1982 - "Retinoid acid in the treatment of hyperkeratosis lenticularis perstans Flegel."
7.	Ointments (Pastes)IBA 03/01/2005 - "Zinc paste bandages and the treatment of Flegel's disease."
8.	Horseradish PeroxidaseIBA 06/01/1978 - "Biopsies of the hyperkeratinized papules of Kyrle-Flegel disease were incubated in vitro with the intercellular tracer, horseradish peroxidase, and the extent of penetration of this substance examined in the light and electron microscopes. "
9.	Ficusin (Psoralen)IBA 02/01/2000 - "We report a patient with Flegel's disease who responded to psoralen ultraviolet A treatment." 02/01/2000 - "Flegel's disease treated with psoralen ultraviolet A."
10.	Etretinate FDA Link 02/15/1986 - "A case of hyperkeratosis lenticularis perstans was successfully treated with etretinate. " 02/15/1986 - "[Tigason in hyperkeratosis lenticularis perstans (HLP)--a case report]."

Therapies and Procedures

1.	Therapeutics 11/01/2008 - "We report on a woman with Flegel's disease who responded to a topical corticosteroid therapy with betamethasone dipropionate."