X-linked Reticuloendotheliosis

An X-linked disease where cells of the RETICULOENDOTHELIAL SYSTEM exhibit abnormal growth and proliferation. Onset occurs in infancy and is characterized by fever, JAUNDICE; LYMPHADENOPATHY; and enlargement of the liver and spleen (hepatosplenomegaly). OMIM: 312500

Also Known As:

Networked: 100 relevant articles (1 outcomes, 5 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Shock
2.	Langerhans-Cell Histiocytosis (Histiocytosis, Langerhans Cell)
3.	Neoplasms (Cancer)
4.	Marek Disease (Marek's Disease)
5.	Avian Leukosis

Experts

1.	Fadly, Aly: 2 articles (12/2013 - 08/2008)
2.	Bahnson, Charlie: 1 article (07/2022)
3.	Fenton, Heather M A: 1 article (07/2022)
4.	Keel, M Kevin: 1 article (07/2022)
5.	Kunkel, Melanie R: 1 article (07/2022)
6.	Munk, Brandon: 1 article (07/2022)
7.	Nemeth, Nicole M: 1 article (07/2022)
8.	Niedringhaus, Kevin D: 1 article (07/2022)
9.	Radisic, Rebecca: 1 article (07/2022)
10.	Sánchez, Susan: 1 article (07/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to X-linked Reticuloendotheliosis:

1.	Vitamin A (Retinol)FDA LinkGeneric 02/01/1952 - "[Mixed form of reticuloendotheliosis; spectacular improvement with vitamin A shock]."
2.	Estrogens (Estrogen)FDA Link 01/01/1946 - "The carcino-resistance of the guinea pig; reticuloendotheliosis, sclerosus and experimental tumors following the administration of hormonal factors, in particular estrogens, and chemical or bacterial exogenous factors." 05/01/1955 - "[Experimental study of reticuloendotheliosis caused by estrogens and sesame oil; their morphological identity. " 11/01/1954 - "[Experimental study of reticuloendotheliosis induced by estrogens and sesame oil: its morphological identity. "
3.	Sesame Oil (Oil, Sesame)IBA 05/01/1955 - "[Experimental study of reticuloendotheliosis caused by estrogens and sesame oil; their morphological identity. " 11/01/1954 - "[Experimental study of reticuloendotheliosis induced by estrogens and sesame oil: its morphological identity. "
4.	AntibodiesIBA 01/01/1995 - "Serologic evidence of antibodies in humans to avian leukosis/sarcoma viruses (ALSV) and reticuloendotheliosis viruses (REV) has in general been negative. " 01/01/1995 - "Detection of antibodies to avian leukosis/sarcoma viruses and reticuloendotheliosis viruses in humans by western blot assay." 01/01/1995 - "Detection of antibodies to avian leukosis/sarcoma viruses (ALSV) and reticuloendotheliosis viruses (REV) in humans by ELISA." 01/01/1976 - "Antibodies to reticuloendotheliosis (3/24) and avain leukosis virus subgroup A (2/24) were present. " 09/01/1973 - "The DNA polymerase activity of disrupted virions of all of the reticuloendotheliosis viruses was not neutralized by any of the antibodies. "
5.	EnzymesIBA 01/01/1966 - "[Histochemical study of lipolytic enzyme activity in specific granulatin tissue in lipoid reticuloendotheliosis (Hand-Schüller-Christian disease)]." 01/01/1988 - "An enzyme-linked immunosorbent assay (ELISA) is described for the detection of reticuloendotheliosis viruses (REVs). " 01/01/1977 - "All of the enzymes inactivated the viral infectivities except for EcoRI, which did not inactivate the infectivity of the DNA of two of the reticuloendotheliosis viruses, spleen necrosis and chick syncytial viruses. " 10/01/1985 - "Activities of phosphoenolpyruvate carboxykinase, a key gluconeogenic enzyme in the liver, were reduced approximately 40 and 50%, respectively, by infection with reticuloendotheliosis-associated virus and reticuloendotheliosis virus. " 05/01/1996 - "A non-radioactive method for identifying enzyme-amplified products of the reticuloendotheliosis proviral env and LTR genes using psoralen-biotin labelled probes."
6.	A-Form DNA (A-DNA)IBA 11/01/1974 - "The reticuloendotheliosis viruses, therefore, replicate through a DNA intermediate. " 12/01/1973 - "The relatedness of the RNAs of the three avian systems, including six avian leukosis-sarcoma viruses, four reticuloendotheliosis viruses, and the microsome fraction of normal uninfected chicken embryo cells, containing RNA and a DNA polymerase have been studied by nucleic acid hybridization. " 05/01/1974 - "Specific serological relationships were found among the partially purified DNA polymerases of the two groups of avian viruses whose virions contain RNA and a DNA polymerase-the avian leukosis-sarcoma viruses and the reticuloendotheliosis viruses-and three avian species which are natural hosts for these viruses: chickens, turkeys, and Pekin ducks. " 09/01/1973 - "Antibodies against a large and a small DNA polymerase isolated from chicken embryos and against avian myeloblastosis virus DNA polymerase were used to study the serological relationships of the DNA polymerase activities of three avian systems with RNA and a DNA polymerase-avian leukosis-sarcoma viruses, reticuloendotheliosis viruses, and a fraction from uninfected chicken cells. "
7.	RNA (Ribonucleic Acid)IBA 01/01/1975 - "Polypeptide and RNA composition of the reticuloendotheliosis viruses." 12/01/1973 - "The relatedness of the RNAs of the three avian systems, including six avian leukosis-sarcoma viruses, four reticuloendotheliosis viruses, and the microsome fraction of normal uninfected chicken embryo cells, containing RNA and a DNA polymerase have been studied by nucleic acid hybridization. " 12/01/1973 - "The RNA template of the endogenous RNA-directed DNA polymerase activity of normal uninfected chicken cells had no detectable relationship to RNAs of avian leukosis-sarcoma and reticuloendotheliosis viruses." 05/01/1974 - "Specific serological relationships were found among the partially purified DNA polymerases of the two groups of avian viruses whose virions contain RNA and a DNA polymerase-the avian leukosis-sarcoma viruses and the reticuloendotheliosis viruses-and three avian species which are natural hosts for these viruses: chickens, turkeys, and Pekin ducks. " 09/01/1973 - "Antibodies against a large and a small DNA polymerase isolated from chicken embryos and against avian myeloblastosis virus DNA polymerase were used to study the serological relationships of the DNA polymerase activities of three avian systems with RNA and a DNA polymerase-avian leukosis-sarcoma viruses, reticuloendotheliosis viruses, and a fraction from uninfected chicken cells. "
8.	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 05/01/1974 - "Specific serological relationships among partially purified DNA polymerases of avian leukosis-sarcoma viruses, reticuloendotheliosis viruses, and avian cells." 09/01/1973 - "Lack of serological relationship among DNA polymerases of avian leukosis-sarcoma viruses, reticuloendotheliosis viruses, and chicken cells." 09/01/1973 - "The DNA polymerase activity of disrupted virions of all of the reticuloendotheliosis viruses was not neutralized by any of the antibodies. " 05/01/1974 - "Specific serological relationships were found among the partially purified DNA polymerases of the two groups of avian viruses whose virions contain RNA and a DNA polymerase-the avian leukosis-sarcoma viruses and the reticuloendotheliosis viruses-and three avian species which are natural hosts for these viruses: chickens, turkeys, and Pekin ducks. " 09/01/1973 - "Antibodies against a large and a small DNA polymerase isolated from chicken embryos and against avian myeloblastosis virus DNA polymerase were used to study the serological relationships of the DNA polymerase activities of three avian systems with RNA and a DNA polymerase-avian leukosis-sarcoma viruses, reticuloendotheliosis viruses, and a fraction from uninfected chicken cells. "
9.	Thorium Dioxide (Thorotrast)IBA 07/20/1967 - "II. Cytological study with the electron microscope of experimental reticuloendotheliosis caused by small doses of thorotrast]."
10.	Proteins (Proteins, Gene)FDA Link 06/01/2007 - "The TLR adapter proteins, myeloid differentiation primary response gene 88 and TLR adaptor molecule 1, as well as v-rel reticuloendotheliosis viral oncogene homolog and NFKBIA, were prominent in testis, epididymis, and vas deferens. " 12/01/2002 - "A system previously developed using reticuloendotheliosis (REV)-transformed cell lines stably expressing individual MDV genes allows the determination of relevant MDV proteins for the induction of cytotoxic T lymphocyte (CTL) responses. " 01/01/2021 - "While examining how targeting USP14 may affect other proteins in vivo, this report showed that fatty acid synthase, v-rel reticuloendotheliosis viral oncogene homolog, CTNNB1, and synaptosome associated protein 23 are reduced in USP14-deficient mice; however, loss of USP14 differentially altered the levels of these proteins in the liver and brain. " 03/01/2012 - "DC nuclear factor (NF)-κB transcription factor reticuloendotheliosis viral oncogene homologue B (RELB) and IL-12p70 protein expression were also determined. " 03/12/2019 - "A variety of these proteins are associated with the non-canonical nuclear factor κB (NF-κB) pathway (nuclear factor κB (NFKB) 2, v-rel reticuloendotheliosis viral oncogene homolog (REL) B, indolamin-2,3-dioxygenase (IDO), kynureninase (KYNU)) or involved in the negative regulation of the canonical NF-κB system. "

Therapies and Procedures

1.	Therapeutics 11/03/1958 - "[Case of panmyelopathia with symptomatic reticuloendotheliosis after antisyphilis therapy]." 01/06/1953 - "[Premalignant cutaneous reticuloendotheliosis of a special type; test of hexanestrol therapy]." 08/01/1953 - "[Therapy of reticuloendotheliosis (Abt-Letterer-Siwe disease)]." 01/01/1956 - "[Effects of ACTH therapy on clinical and morphological symptoms in a case of acute reticuloendotheliosis (Abt-Letterer-Siwe's disease)]."
2.	Splenectomy 01/01/1955 - "[Splenomegalic benign reticuloendotheliosis with hypereosinophilia; results of splenectomy]." 05/01/1954 - "[Hepatosplenopathy of the reticuloendotheliosis type with anemia in monozygotic twins; splenectomy in the most severe case and remote considerations]."
3.	X-Ray Therapy 02/24/1957 - "[Report of a case of systemic reticuloendotheliosis (histiocytosis X); effect of 6-mercaptopurine, prednisone and roentgenotherapy]."
4.	Radiotherapy 06/01/1950 - "[Reticuloendotheliosis; successful radiotherapy of a severe case of Hand-Schuller-Christian disease]."
5.	Drug Therapy (Chemotherapy) 10/01/1974 - "Chemotherapy of reticuloendotheliosis. "