Acquired angioedema

A type of angioedema characterized by transitory and recurrent subcutaneous or submucosal edemas resulting in swelling and/or abdominal pain due to an acquired C1 inhibitor (C1-INH) deficiency (OMIM: 300909).

Networked: 136 relevant articles (5 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

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4.	Spondylarthropathies
5.	Relapsing-Remitting Multiple Sclerosis

Experts

1.	Cicardi, Marco: 11 articles (08/2018 - 07/2003)
2.	Zanichelli, Andrea: 10 articles (08/2018 - 07/2010)
3.	Boccon-Gibod, Isabelle: 5 articles (01/2021 - 10/2012)
4.	Bouillet, Laurence: 5 articles (01/2021 - 10/2012)
5.	Caballero, T: 5 articles (12/2019 - 01/2011)
6.	Farkas, Henriette: 4 articles (01/2021 - 05/2006)
7.	Castelli, Roberto: 4 articles (08/2018 - 12/2008)
8.	Varga, Lilian: 3 articles (01/2021 - 05/2006)
9.	Levi, Marcel: 3 articles (01/2019 - 04/2006)
10.	López-Trascasa, M: 3 articles (01/2018 - 01/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Acquired angioedema:

1.	Rituximab (Mabthera)FDA Link 01/01/2014 - "Treatment with rituximab resulted in complete clinical and biochemical remission of the acquired angioedema. " 01/01/2019 - "Long-term effects upon rituximab treatment of acquired angioedema due to C1-inhibitor deficiency." 10/01/2012 - "Rituximab efficacy in the treatment of acquired angioedema is inconstant and might require repeated cycles." 10/01/2012 - "Description of 7 rituximab-treated patients, 6 with type II acquired angioedema and 1 with type I. Clinical efficacy (only for type II) was complete for 3, partial for 2 and 2 were therapeutic failures. " 10/01/2011 - "Acquired angioedema responding to rituximab."
2.	Histamine Antagonists (Antihistamines)IBA 01/01/2021 - "Idiopathic nonhistaminergic acquired angioedema should be considered when all other types of recurrent angioedema have been ruled out and patients do not respond to high-dose antihistamines. " 01/01/2017 - "Idiopathic non-histaminergic acquired angioedema (InH-AAE) is a rare disease characterized by AE resistant to antihistamines and a chronic course. " 01/01/2021 - "Idiopathic histaminergic acquired angioedema may be diagnosed only when any possible causes of histaminergic angioedema are excluded (foods, drugs, animal dander, aeroallergens, insect stings, latex, and others), and the symptoms respond well to antihistamine treatment. " 01/01/2019 - "Corticosteroids and antihistamines, which are usually beneficial in histamine-induced acquired angioedema, are not effective in HAE. "
3.	Histamine (Histamine Dihydrochloride)FDA Link 01/01/2019 - "Swelling, that is the most common initial finding, may mimic hereditary or acquired angioedema, a disorder caused by histamine or bradykinin-mediated plasma-leakage affecting subcutaneous and/or submucosal tissue. " 01/01/2016 - "Histamine is the mediator in acquired angioedema of unknown etiology (idiopathic histaminergic acquired angioedema), whereas in other forms the main mediator is bradykinin. " 01/01/2019 - "Corticosteroids and antihistamines, which are usually beneficial in histamine-induced acquired angioedema, are not effective in HAE. "
4.	lanadelumabIBA 01/01/2021 - "Efficacy of lanadelumab in acquired angioedema with C1-inhibitor deficiency." 07/03/2023 - "Life-threatening idiopathic nonhistaminergic acquired angioedema with response to lanadelumab."
5.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/2019 - "Corticosteroids and antihistamines, which are usually beneficial in histamine-induced acquired angioedema, are not effective in HAE. "
6.	AutoantibodiesIBA 06/01/2002 - "To study the characteristics of autoantibodies to C1-INH in a patient with acquired angioedema. " 12/01/2019 - "Serum complexes between C1INH and C1INH autoantibodies for the diagnosis of acquired angioedema." 01/01/2018 - "Acquired Angioedema With Anti-C1-inhibitor Autoantibodies During Assisted Reproduction Techniques." 10/01/2016 - "Acquired angioedema with C1-INH deficiency type I is characterized by the low C1-INH function and concentration; however, C1q concentration is also low, and autoantibodies against C1-INH cannot be detected. " 09/01/2010 - "Acquired angioedema: Autoantibody associations and C1q utility as a diagnostic tool."
7.	factor V LeidenIBA 05/01/2006 - "Deep venous thrombosis associated with acquired angioedema type II in a patient heterozygous for the mutation of factor V Leiden: effective treatment and follow-up for four years." 03/01/2006 - "The purpose of this study is to report a case of acquired angioedema and Factor V Leiden mutation in a woman who had started taking an oral contraceptive (OC), and to review the literature. " 03/01/2006 - "Skin venous thromboembolism by combined oral contraceptive in a woman with acquired angioedema and Factor V Leiden mutation."
8.	Oral ContraceptivesIBA 03/01/2006 - "The purpose of this study is to report a case of acquired angioedema and Factor V Leiden mutation in a woman who had started taking an oral contraceptive (OC), and to review the literature. "
9.	BradykininIBA 05/01/2022 - "However, after further testing, she was diagnosed with acquired angioedema and subsequently treated with a synthetic bradykinin B2-receptor antagonist." 01/01/2021 - "Acquired angioedema due to C1-inhibitor deficiency (C1-INH-AAE) is a rare form of bradykinin-mediated angioedema. " 12/01/2020 - "Acquired angioedema with C1-inhibitor deficiency is a rare and peculiar entity belonging to the spectrum of bradykinin angioedemas. " 12/01/2019 - "Acquired angioedema due to C1-inhibitor (C1INH) deficiency (AAE) is caused by secondary C1INH deficiency leading to bradykinin-mediated angioedema episodes. " 01/01/2013 - "Acquired C1 inhibitor (C1-INH) deficiency exposes patients to angioedema recurrences (acquired angioedema [AAE]) mediated by bradykinin pathway activation. "
10.	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 01/01/2021 - "Currently, no laboratory method is available for identifying acquired angioedema related to angiotensin-converting enzyme inhibitors. " 04/01/2015 - "No specific drugs are licensed for the treatment of ACE inhibitor (ACEI)-acquired angioedema (ACEI-AAE). " 07/01/2008 - "The use of angiotensin-converting enzyme inhibitors (ACEI) has become the leading cause of acquired angioedema. " 09/23/1999 - "[Acquired angioedema during ACE-inhibitor therapy]." 01/01/2021 - "The lack of a standard biochemical laboratory test for patients with idiopathic histaminergic acquired angioedema, idiopathic nonhistaminergic acquired angioedema, angiotensin-converting enzyme inhibitor-induced acquired angioedema, and hereditary angioedema with normal C1 inhibitor makes the diagnosis more challenging. "

Therapies and Procedures

1.	Stem Cell Transplantation 10/01/2015 - "Non-myeloablative allogeneic stem cell transplantation: a new treatment option for acquired angioedema?"
2.	Therapeutics 09/15/2023 - "Acquired Angioedema Due to C1-Inhibitor Deficiency (AAE-C1-INH)-A Bicenter Retrospective Study on Diagnosis, Course, and Therapy." 11/01/2003 - "One was considered to be a type 2 acquired angioedema, which tolerates replacement therapy with fresh frozen plasma. " 09/01/1992 - "Replacement therapy in hereditary and acquired angioedema." 09/01/2017 - "Acquired angioedema due to C1-inhibitor deficiency (C1-INH-AAE) is a rare disease with no prevalence data or approved therapies. " 01/01/2013 - "A patient with chronic lymphocytic leukemia and acquired angioedema: correlation of clinical and biochemical response to CLL therapy."
3.	Airway Management 02/01/2003 - "Following definitive airway management, investigation showed a diagnosis of acquired C1 esterase inhibitor deficiency (acquired angioedema) that was considered to be subsequent to haematological malignancy. "
4.	Hormone Replacement Therapy (Therapy, Hormone Replacement) 10/01/2005 - "To the best of our knowledge, this case probably represents the first reported case of acquired angioedema secondary to hormone replacement therapy." 10/01/2005 - "Acquired angioedema secondary to hormone replacement therapy." 10/01/2005 - "We present a review of reported cases of hormonally induced hereditary angioedema, along with a report of a patient with acquired angioedema secondary to hormone replacement therapy. "
5.	Heart Transplantation (Grafting, Heart) 03/01/2014 - "A cohort of 207 children and adolescents who had undergone heart transplantation were assessed at regular follow-up examinations for incidence of acquired angioedema. "