Kyrle disease

Follicular keratosis (Darier Disease) characterized by horny papules that can occur anywhere except the palms, soles, and mucous membranes. They may last several weeks and eventually acquire a central keratotic plug that, upon removal, leaves a crater that matches the shape of the plug (Kyrle sign). Some patients may also develop posterior, subcapsular CATARACTS. OMIM: 149500

Also Known As:

Hyperkeratosis follicularis et parafollicularis in cutem penetrans; Kyrle's disease

Networked: 20 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Uremia
2.	Skin Diseases (Skin Disease)
3.	Pruritus (Itching)
4.	Pityriasis Rubra Pilaris
5.	Darier Disease (Darier's Disease)

Experts

1.	Akiyama, Masashi: 1 article (12/2020)
2.	Ishida-Yamamoto, Akemi: 1 article (12/2020)
3.	Kawakami, Tamihiro: 1 article (12/2020)
4.	Mitoma, Chikage: 1 article (12/2020)
5.	Nakano, Hajime: 1 article (12/2020)
6.	Suga, Yasushi: 1 article (12/2020)
7.	Yoneda, Kozo: 1 article (12/2020)
8.	Fetil, Emel: 1 article (03/2020)
9.	Lebe, Banu: 1 article (03/2020)
10.	Ozbagcivan, Ozlem: 1 article (03/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Kyrle disease:

1.	Tacrolimus (Prograf)FDA LinkGeneric 05/01/2017 - "Efficacy of topical tacrolimus for treating Kyrle's disease."
2.	Isotretinoin (Accutane)FDA LinkGeneric 09/01/2018 - "Kyrle's disease effectively treated with oral isotretinoin."
3.	Acitretin FDA Link 04/15/1989 - "[The Kyrle disease entity and its therapeutic modification by acitretin (etretin)]." 07/01/2015 - "A diagnosis of Kyrle's disease was made and patient was started on oral acitretin 25 mg daily with satisfactory response to therapy. "
4.	Vitamin A (Retinol)FDA LinkGeneric 06/15/1975 - "In a female patient suffering from Kyrle's disease, the serum level of retinol was found in the lower part of the normal range. " 01/01/1973 - "Pilot studies of serum level of vitamin A and liver function tests during administration of retinoic acid in hyperkeratosis follicularis et parafollicularis (Kyrle's disease), pityriasis rubra pilaris, and keratosis follicularis (Darier's disease)."
5.	Tretinoin (Retinoic Acid)FDA LinkGeneric 06/15/1975 - "Several possibilities regarding the treatment of Kyrle's disease as well as the mode of action of vitamin A acid are discussed." 06/15/1975 - "[Kyrle's disease (hyperketarosis follicularis et parafollicularis): local and systemic therapy with vitamin A acid (retinoic acid)]." 01/01/1973 - "Pilot studies of serum level of vitamin A and liver function tests during administration of retinoic acid in hyperkeratosis follicularis et parafollicularis (Kyrle's disease), pityriasis rubra pilaris, and keratosis follicularis (Darier's disease)."
6.	Proteins (Proteins, Gene)FDA Link 07/01/1986 - "Kyrle's disease may be caused and promoted by association with other diseases going along with hyperkeratosis and causing damage to tissue proteins by non-enzymatic glycosylation (e. " 09/01/1980 - "The pattern of phosphorylation of these SDS-beta-mercaptoethanol soluble epidermal proteins is not changed in basal cell carcinoma, icthyosis vulgaris, Kyrle's disease or Netherton's syndrome. "
7.	Keratins (Keratin)IBA 12/01/2020 - "Kyrle's disease presents with transepidermal elimination of abnormal keratin. " 07/01/2018 - "Kyrle's disease (KD) is a rare skin pathology characterized by transepidermal elimination of abnormal keratin. "
8.	mu Opioid Receptors (mu Opioid Receptor)IBA 12/01/2019 - "The novel use of mu-opioid receptor antagonism for the treatment of refractory pruritus in Kyrle's disease."
9.	Vitamin D FDA LinkGeneric 12/01/1981 - "Since all of these patients had renal disease, we hypothesize that an abnormality in the renal-calcium-vitamin D-parathyroid chain allows the pathologic accumulation of keratinous debris that characterizes Kyrle's disease. "
10.	Phosphorus (Red Phosphorus)IBA 07/01/1996 - "So it is probable that the elevated phosphorus may be triggering the occurrence of Kyrle's disease."

Therapies and Procedures

1.	Therapeutics 07/01/2015 - "A diagnosis of Kyrle's disease was made and patient was started on oral acitretin 25 mg daily with satisfactory response to therapy. " 06/15/1975 - "[Kyrle's disease (hyperketarosis follicularis et parafollicularis): local and systemic therapy with vitamin A acid (retinoic acid)]."
2.	Renal Dialysis (Hemodialysis) 09/01/2015 - "Kyrle disease is one of the perforating dermatoses associated with diabetic patients undergoing renal dialysis. " 01/01/2016 - "We report Kyrle's disease in a middle aged female suffering from diabetes mellitus with diabetic nephropathy on hemodialysis."
3.	Transjugular Intrahepatic Portasystemic Shunt 03/01/2020 - "Herein we report our dermoscopic observation with additional diagnostic tips in a case who was diagnosed with Kyrle's disease histopathologically."