Heterochromia iridis

Asymmetry of iris pigmentation. It may occur in cases of HORNER SYNDROME; WAARDENBURG SYNDROME; or PIEBALDISM. OMIM: 142500

Also Known As:

Asymmetry in the pigmentation of the irides; Pigmentary abnormality of the anterior segment of the eye

Networked: 7 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Eye Diseases: 3522
- Uveal Diseases: 16
  - Iris Diseases: 5
    - Heterochromia iridis: 7
Skin and Connective Tissue Diseases
- Skin Diseases: 13127
  - Pigmentation Disorders: 149
    - Heterochromia iridis: 7
Signs and Symptoms Pathological Conditions
- Pathologic Processes: 10023
  - Pigmentation Disorders: 149
    - Heterochromia iridis: 7

Related Diseases

1.	Corneal Edema
2.	Ophthalmoplegia (External Ophthalmoplegia)
3.	Keratitis
4.	Waardenburg Syndrome (Klein Syndrome)
5.	Hearing Loss (Hearing Impairment)

Experts

1.	Gionfriddo, Juliet R: 1 article (09/2018)
2.	Good, Kathryn L: 1 article (09/2018)
3.	Knickelbein, Kelly E: 1 article (09/2018)
4.	Maggs, David J: 1 article (09/2018)
5.	Reilly, Christopher M: 1 article (09/2018)
6.	Bahrami, Tayeb: 1 article (12/2015)
7.	Emamdjomeh, Hesam: 1 article (12/2015)
8.	Farhadi, Mohammad: 1 article (12/2015)
9.	Jalilian, Nazanin: 1 article (12/2015)
10.	Noori-Daloii, Mohammad Reza: 1 article (12/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Heterochromia iridis:

1.	SteroidsIBA 10/01/2006 - "Corneal epithelial defect, corneal edema, secondary bacterial keratitis, heterochromia iridis, and internal ophthalmoplegia were identified The corneal edema markedly improved 3 days after removing the retained bee stingers and treatment by topical antibiotics and steroids. "
2.	Anti-Bacterial Agents (Antibiotics)IBA 10/01/2006 - "Corneal epithelial defect, corneal edema, secondary bacterial keratitis, heterochromia iridis, and internal ophthalmoplegia were identified The corneal edema markedly improved 3 days after removing the retained bee stingers and treatment by topical antibiotics and steroids. "
3.	Melanins (Melanin)IBA 09/01/2018 - "Clinical evaluation of the 2-year-old son of Alpaca 1 revealed iris colobomata OU and choroidal dysplasia/hypoplasia OD in addition to nonpathologic variations in melanin density including heterochromia iridis and a subalbinotic fundus OU. " 01/01/1998 - "A defect in neural crest cell migration and melanin synthesis may be responsible for the heterochromia iridis seen in Waardenburg syndrome type II."
4.	Nonsense Codon (Nonsense Mutation)IBA 05/01/2014 - "We identified a de novo nonsense mutation in SOX10 (p.G39X) in a female pediatric patient with Waardenburg syndrome with heterochromia iridis, profound bilateral sensorineural hearing loss, inner ear malformations, and overall hypopigmentation of the hair without dystopia canthorum. "
5.	OF 900IBA 05/01/1992 - "In a survey of 900 Dalmatian dogs, brainstem auditory-evoked responses (BAER) and clinical observations were used to determine the incidence and sex distribution of bilateral and unilateral BAER abnormalities and their association with heterochromia iridis (HI). "
6.	brilliant blue (brilliant blue FCF)IBA 12/15/2015 - "Early graying, hair discoloration, hypoplastic blue eyes (characteristic brilliant blue iris) and hearing loss were the most common features observed, while heterochromia iridis was the least frequently observed sign among the studied Iranian WS1 patients. "

Therapies and Procedures

1.	Telescopes 09/01/1965 - "A pedigree of binocular heterochromia iridis associated with other anomalies (Waardenburg-Klein syndrome)."
2.	Iridectomy 01/01/1998 - "Evaluation of 4-month-old girl who presented with congenital cataracts revealed heterochromia iridis, fundus hypopigmentation, residual white forelock and sensory neural hearing loss--findings consistent with Waardenburg syndrome type II. Bilateral peripheral iridectomies performed at lensectomy provided tissue for evaluation. "