Fetal hydantoin syndrome

07/01/1989 - "The role of GSH in protection against phenytoin embryopathy was studied by altering GSH homeostasis using 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), an inhibitor of glutathione reductase. "

07/01/1989 - "The role of GSH in protection against phenytoin embryopathy was studied by altering GSH homeostasis using 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU), an inhibitor of glutathione reductase. "

10/01/1981 - "These abnormalities resemble those reported for the Fetal Hydantoin Syndrome and provide a means to study the effect of phenytoin on the morphological and biochemical development of the fetus."
08/01/2008 - "Specifically, fetal exposure to phenytoin is linked to fetal hydantoin syndrome in humans. "
11/01/2004 - "Prenatal exposure to phenytoin may result in a spectrum of structural, developmental and behavioural changes, known as the fetal hydantoin syndrome. "
08/01/2003 - "Prenatal exposure to phenytoin may result in a spectrum of structural, developmental, and behavioral changes known as the fetal hydantoin syndrome. "
10/01/2001 - "The influence of Phenytoin on the human embryo is knowing to produce the fetal hydantoin syndrome. "

08/01/1989 - "This study examined the effects of the GSH depletor diethyl maleate (DEM) and the GSH synthesis inhibitor L-buthionine-(S,R)-sulfoximine (BSO) on phenytoin embryopathy. "

08/01/1989 - "This study examined the effects of the GSH depletor diethyl maleate (DEM) and the GSH synthesis inhibitor L-buthionine-(S,R)-sulfoximine (BSO) on phenytoin embryopathy. "

05/01/2016 - "The two children with NFNS phenotype presented with NF1 signs inherited from their father and fetal hydantoin syndrome-like phenotype due to exposure to that anticonvulsant during fetal development. "
01/01/1983 - "[Teratogenic effect of anticonvulsants with special emphasis on the fetal hydantoin syndrome]."
09/26/1980 - "Infants of epileptic mothers receiving anticonvulsants should be closely examined at birth for the fetal hydantoin syndrome and monitored for hemorrhagic problems. "
10/01/1976 - "A prospective study of 35 infants exposed prenatally to this class of anticonvulsants showed that 11% had sufficient features to be classified as having the fetal hydantoin syndrome. "
09/26/1980 - "This is the first patient report of maternal ingestion of anticonvulsants associated with the triad of fetal hydantoin syndrome, neuroblastoma, and hemorrhagic disease. "

02/01/1988 - "The fetal hydantoin syndrome is an entity that consists of a broad range of morphologic and developmental disorders in children born of epileptic mothers exposed to hydantoin during pregnancy. "
04/01/1985 - "Maternal hydantoin ingestion during pregnancy results in a well defined clinical entity termed "fetal hydantoin syndrome". "
08/01/1981 - "Prenatal exposure to hydantoins may result in a spectrum of structural, developmental, and behavioral changes known as the fetal hydantoin syndrome (FHS). "
10/21/1979 - "[Fetal hydantoin syndrome (side effects of hydantoin preparations)]."
10/01/1976 - "The fetal hydantoin syndrome is a variable pattern of altered growth and performance which includes unusual facies, distal phalangeal hyoplasia, and other defects occurring in some infants exposed in utero to hydantoins. "

04/01/1985 - "Therefore, we studied in vivo placental folate transport in a well-established model for fetal hydantoin syndrome in the rat. "
04/01/1985 - "Fetal hydantoin syndrome: inhibition of placental folic acid transport as a potential mechanism for fetal growth retardation in the rat."
08/27/1983 - "Maternal serum folate concentrations for infants with structural birth defects, "fetal hydantoin syndrome," or perinatal death were similar to those for healthy babies. "
05/01/1982 - "The anticonvulsant diphenylhydantion (DPH) causes embryonic folate antagonism in the animal model of the fetal hydantoin syndrome. "
04/01/1985 - "Because folic acid is essential for protein synthesis and growth, and since hydantoin interferes with intestinal transport of folic acid, we postulated that part of the fetal hydantoin syndrome may be due to inhibition of placental folic acid by maternal hydantoin. "

07/17/1996 - "epoxide hydrolase and fetal hydantoin syndrome). "
12/01/1995 - "A lower microsomal epoxide hydrolase (mEH) activity has been associated with increased likelihood of fetal hydantoin syndrome. "
12/01/1995 - "Phenytoin embryopathy: effect of epoxide hydrolase inhibitor on phenytoin exposure in utero in C57BL/6J mice."

11/01/2002 - "Here, we determined in embryo culture whether the Ras pathway mediated phenytoin embryopathy at the protein or gene level. "
04/01/1985 - "Because folic acid is essential for protein synthesis and growth, and since hydantoin interferes with intestinal transport of folic acid, we postulated that part of the fetal hydantoin syndrome may be due to inhibition of placental folic acid by maternal hydantoin. "

04/01/1982 - "Anticonvulsant therapy during pregnancy with the hydantoin phenytoin carries a risk of teratologic sequelae and developmental retardation known as the fetal hydantoin syndrome. "

11/01/1982 - "[Anesthesia in an infant with fetal hydantoin syndrome]."