Jensen syndrome

Also Known As:

Nerve deafness optic nerve atrophy, and dementia; Opticoacoustic Nerve Atrophy With Dementia; Opticoacustic nerve atrophy with dementia; Syndrome of opticoacoustic nerve atrophy with dementia

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Nervous System Diseases: 14178
Mental Disorders: 24177
- Neurocognitive Disorders: 1448
  - Dementia: 38184
    - Jensen syndrome: 1
Otorhinolaryngologic Diseases: 203
- Ear Diseases: 261
  - Hearing Disorders: 325
    - Hearing Loss: 12265
      - Sensorineural Hearing Loss: 3974
        Central Hearing Loss: 6
        Jensen syndrome: 1
  - Retrocochlear Diseases: 5
    - Central Auditory Diseases: 12
      - Central Hearing Loss: 6
        Jensen syndrome: 1
Signs and Symptoms Pathological Conditions
- Signs and Symptoms
  - Neurologic Manifestations: 7102
    - Sensation Disorders: 117
      - Hearing Disorders: 325
        Hearing Loss: 12265
        Sensorineural Hearing Loss: 3974
        Central Hearing Loss: 6
        Jensen syndrome: 1
Eye Diseases: 3522
- Optic Nerve Diseases: 2663
  - Optic Atrophy: 819
    - Jensen syndrome: 1

Related Diseases

1.	Intellectual Disability (Idiocy)

Experts

1.	Hatch, Hayden A M: 1 article (09/2021)
2.	Secombe, Julie: 1 article (09/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Jensen syndrome:

1.	Histone DemethylasesIBA 12/01/2022 - "Molecular and cellular events linking variants in the histone demethylase KDM5C to the intellectual disability disorder Claes-Jensen syndrome." 12/01/2022 - "One gene found to be genetically altered in the X-linked intellectual disability disorder Claes-Jensen syndrome is KDM5C, which encodes a histone demethylase that regulates transcription by altering chromatin. "
2.	ChromatinIBA 12/01/2022 - "One gene found to be genetically altered in the X-linked intellectual disability disorder Claes-Jensen syndrome is KDM5C, which encodes a histone demethylase that regulates transcription by altering chromatin. "

Therapies and Procedures

1.	Therapeutics 12/01/2022 - "Continued research into the molecular and cellular activities regulated by KDM5C is expected to provide critical etiological insights into Claes-Jensen syndrome and highlight potential targets for developing therapies to improve the quality of life of those affected."