Jacobs syndrome

Also Known As:

Arthropathy camptodactyly syndrome; Arthropathy-Camptodactyly Syndrome; Camptodactyly arthropathy pericarditis syndrome; Camptodactyly-Arthropathy-Pericarditis Syndrome; Camptodactyly-arthropathy-coxa vara-pericarditis syndrome; Congenital familial hypertrophic synovitis; Fibrosing serositis, familial; Hypertrophic Synovitis, Congenital Familial; Pericarditis arthropathy camptodactyly syndrome; Pericarditis-Arthropathy-Camptodactyly Syndrome

Networked: 9 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Joint Diseases (Joint Disease)
2.	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders)
3.	Hyperplasia

Experts

1.	Jay, Gregory D: 2 articles (01/2015 - 03/2005)
2.	Warman, Matthew L: 2 articles (01/2015 - 03/2005)
3.	Al-Mayouf, Sulaiman Mohammed: 1 article (02/2017)
4.	Alismail, Khalid: 1 article (02/2017)
5.	Almutairi, Nora: 1 article (02/2017)
6.	Ai, Minrong: 1 article (01/2015)
7.	Cui, Yajun: 1 article (01/2015)
8.	Kurek, Kyle C: 1 article (01/2015)
9.	Larson, Katherine M: 1 article (01/2015)
10.	Lee, David M: 1 article (01/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Jacobs syndrome:

1.	Yttrium-90IBA 02/05/2017 - "The Efficacy of Yttrium-90 Radiosynovectomy in Patients with Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome."
2.	lubricinIBA 12/01/2022 - "Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) is a joint disease caused by a lack of lubricin, resulting in failed lubrication and abnormal deposition at the cartilage surface. " 06/01/2011 - "Moreover, mutations or lacking of lubricin gene have been shown to link to the joint disease such as camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP), synovial hyperplasia and failure of joint function, suggesting an important role of lubricin in the pathogenesis of these joint disease. " 01/01/2015 - "The mAbs were specific for lubricin since they did not cross-react with other synovial fluid constituents from patients with camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP), who genetically lack this protein. " 03/01/2005 - "Loss-of-function mutations in lubricin (a secreted glycoprotein encoded by the gene PRG4) cause the human autosomal recessive disorder camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP). "
3.	Proteoglycans (Proteoglycan)IBA 12/01/2022 - "Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome: The First Familial Case in China and Novel Mutations of the Proteoglycan 4 Gene." 11/01/1999 - "CACP, encoding a secreted proteoglycan, is mutated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome." 07/01/2012 - "Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) is a clinically heterogenous congenital disorder caused by mutations in proteoglycan 4 (PRG4), a chondroitin sulfate proteoglycan that acts as a lubricant for the cartilage surface. "
4.	LubricantsIBA 07/01/2012 - "Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) is a clinically heterogenous congenital disorder caused by mutations in proteoglycan 4 (PRG4), a chondroitin sulfate proteoglycan that acts as a lubricant for the cartilage surface. "
5.	Chondroitin Sulfate ProteoglycansIBA 07/01/2012 - "Camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP) is a clinically heterogenous congenital disorder caused by mutations in proteoglycan 4 (PRG4), a chondroitin sulfate proteoglycan that acts as a lubricant for the cartilage surface. "
6.	Proteins (Proteins, Gene)FDA Link 01/01/2015 - "The mAbs were specific for lubricin since they did not cross-react with other synovial fluid constituents from patients with camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP), who genetically lack this protein. "
7.	Glycoproteins (Glycoprotein)IBA 03/01/2005 - "Loss-of-function mutations in lubricin (a secreted glycoprotein encoded by the gene PRG4) cause the human autosomal recessive disorder camptodactyly-arthropathy-coxa vara-pericarditis syndrome (CACP). "

Therapies and Procedures

1.	Hip Replacement Arthroplasty (Total Hip Replacement) 09/01/2012 - "Total hip arthroplasty in adolescents with severe hip arthropathy and dysplasia associated with camptodactyly-arthropathy-coxa vara-pericarditis syndrome."