Multifocal fibrosclerosis

A hereditary autosomal recessive connective tissue disorder characterized by retroperitoneal fibrosis, Riedel sclerosing THYROIDITIS; SCLEROSING CHOLANGITIS; ORBITAL PSEUDOTUMOR, seronegative SPONDYLARTHROPATHY; finger CONTRACTURES, camptodactyly, and mediastinal fibrosis. OMIM: 228800

Also Known As:

Networked: 15 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Retroperitoneal Fibrosis
2.	HIV Infections (HIV Infection)
3.	Peritoneal Panniculitis (Sclerosing Mesenteritis)
4.	Localized Scleroderma (Morphea)
5.	Mitral Valve Stenosis (Mitral Stenosis)

Experts

1.	Ciccia, Francesco: 1 article (01/2022)
2.	Mauro, Daniele: 1 article (01/2022)
3.	Raimondi, Maura: 1 article (01/2022)
4.	Scriffignano, Silvia: 1 article (01/2022)
5.	Tirri, Rosella: 1 article (01/2022)
6.	Aiba, Setsuya: 1 article (06/2021)
7.	Chiba, Tomoko: 1 article (06/2021)
8.	Fujii, Hiroshi: 1 article (06/2021)
9.	Kanbayashi, Yumi: 1 article (06/2021)
10.	Mizuashi, Masato: 1 article (06/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Multifocal fibrosclerosis:

1.	Immunoglobulin G (IgG)IBA 12/01/2013 - "There have been no previous case reports of IgG4 non-related systemic multifocal fibrosclerosis with intracardiac involvement. " 12/01/2013 - "After surgical biopsy around the abdominal aortic area in the retroperitoneum, histological examination revealed IgG4 non-related systemic multifocal fibrosclerosis. " 11/01/2012 - "Histopathologic findings showed fibrotic tissue accompanied by proliferation of IgG4-positive plasma cells (proportion of IgG4/IgG-positive plasma cells ≥70%) indicative of multifocal fibrosclerosis." 12/01/2013 - "Here, we report a case of IgG4 non-related systemic multifocal fibrosclerosis mimicking mitral stenosis. " 12/01/2013 - "We present a case of IgG4 non-related systemic multifocal fibrosclerosis mimicking mitral stenosis on echocardiography. "
2.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/2009 - "A diagnosis of multifocal fibrosclerosis was made and corticosteroid treatment started. " 06/01/2002 - "FDG PET can help to establish the diagnosis of multifocal fibrosclerosis and evaluate the activity and patient response to corticosteroid therapy." 12/01/2001 - "The unusual ocular features of this case are briefly discussed and the use of corticosteroid and other immunosuppressant therapy in multifocal fibrosclerosis is reviewed."
3.	Immunoglobulins (Immunoglobulin)IBA 12/01/2013 - "The cardiovascular system may be one of the target organs of both immunoglobulin G4 related and non-related systemic multifocal fibrosclerosis. " 06/01/2021 - "Non-immunoglobulin G4-related multifocal fibrosclerosis presenting generalized morphea-like skin lesions."
4.	Antineutrophil Cytoplasmic Antibodies (ANCA)IBA 07/01/2014 - "Among 159 cases for whom detailed data were collated, antineutrophil cytoplasmic antibody (ANCA)-related HP was found in 54 cases (34.0%) and IgG4/multifocal fibrosclerosis (MFS)-related HP in 14 cases (8.8%). "
5.	SteroidsIBA 12/01/2013 - "We describe the multimodal imaging used to diagnose IgG4 non-related systemic multifocal fibrosclerosis and a positive response to steroid treatment. "
6.	Methysergide (Sansert)FDA Link 06/01/1969 - "[Retroperitoneal fibrosis (Ormond's disease), manifestation of possibly genetically caused, sometimes methysergide induced, multifocal fibrosclerosis]."
7.	Immunosuppressive Agents (Immunosuppressants)IBA 12/01/2001 - "The unusual ocular features of this case are briefly discussed and the use of corticosteroid and other immunosuppressant therapy in multifocal fibrosclerosis is reviewed."
8.	GlucocorticoidsIBA 11/01/2000 - "Glucocorticoids are currently the treatment of choice for progressive multifocal fibrosclerosis. " 11/01/2000 - "We describe a case of multifocal fibrosclerosis and its response to glucocorticoid therapy. "
9.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 02/01/2006 - "[Oral cyclophosphamide therapy for multifocal fibrosclerosis with hypertrophic intracranial pachymeningitis]."
10.	Rituximab (Mabthera)FDA Link 01/01/2022 - "Multifocal fibrosclerosis in a patient with HIV infection treated with rituximab."

Therapies and Procedures

1.	Radiotherapy 05/01/2000 - "External beam radiotherapy may be an effective treatment for intraocular involvement by multifocal fibrosclerosis." 05/01/2000 - "To report the clinical and histopathologic findings of intraocular involvement in a patient with multifocal fibrosclerosis and the response of the patient's choroidal masses to external beam radiotherapy. "
2.	Therapeutics 06/01/2002 - "FDG PET can help to establish the diagnosis of multifocal fibrosclerosis and evaluate the activity and patient response to corticosteroid therapy." 11/01/2000 - "We describe a case of multifocal fibrosclerosis and its response to glucocorticoid therapy. " 02/01/2006 - "[Oral cyclophosphamide therapy for multifocal fibrosclerosis with hypertrophic intracranial pachymeningitis]." 12/01/2001 - "The unusual ocular features of this case are briefly discussed and the use of corticosteroid and other immunosuppressant therapy in multifocal fibrosclerosis is reviewed."