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Spinocerebellar ataxia 8

Also Known As:

SCA8 Spinocerebellar ataxia 8

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Nervous System Diseases: 14178
- Neurodegenerative Diseases: 42472
  - Nervous System Heredodegenerative Disorders: 63
    - Spinocerebellar Degenerations: 353
      - Spinocerebellar ataxia 8: 5
- Central Nervous System Diseases: 4213
  - Brain Diseases: 15694
    - Cerebellar Diseases: 631
      - Spinocerebellar Degenerations: 353
        Spinocerebellar ataxia 8: 5
  - Spinal Cord Diseases: 4314
    - Spinocerebellar Degenerations: 353
      - Spinocerebellar ataxia 8: 5
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - Nervous System Heredodegenerative Disorders: 63
    - Spinocerebellar Degenerations: 353
      - Spinocerebellar ataxia 8: 5

Related Diseases

1.	Neurodegenerative Diseases (Neurodegenerative Disease)
2.	Spinal Muscular Atrophy (Progressive Muscular Atrophy)
3.	Fragile X Tremor Ataxia Syndrome

Experts

1.	Mutsuddi, Mousumi: 2 articles (01/2016 - 02/2004)
2.	Bhaskar, Pradeep K: 1 article (01/2016)
3.	Mukherjee, Ashim: 1 article (01/2016)
4.	Surabhi, Satya: 1 article (01/2016)
5.	Tripathi, Bipin K: 1 article (01/2016)
6.	Vincent, John B: 1 article (01/2016)
7.	Cauchi, Ruben J: 1 article (01/2006)
8.	van den Heuvel, Marcel: 1 article (01/2006)
9.	Benzow, Kellie A: 1 article (02/2004)
10.	Koob, Michael D: 1 article (02/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Spinocerebellar ataxia 8:

1.	Untranslated RNA (Noncoding RNA)IBA 01/01/2016 - "The 13q expansion occurs within a noncoding RNA and appears to be associated with spinocerebellar ataxia 8 (SCA8), but with a still unexplained dichotomy in penetrance - either very high or very low. " 02/17/2004 - "The spinocerebellar ataxia 8 noncoding RNA causes neurodegeneration and associates with staufen in Drosophila." 02/17/2004 - "Spinocerebellar Ataxia 8 (SCA8) appears unique among triplet repeat expansion-induced neurodegenerative diseases because the predicted gene product is a noncoding RNA. "
2.	RNA (Ribonucleic Acid)IBA 01/01/2016 - "Spinocerebellar ataxia 8 (SCA8) pathogenesis is a resultant of gain-of-function machinery that primarily results at the RNA level. " 01/01/2016 - "The RNA binding KH domain of Spoonbill depletes pathogenic non-coding spinocerebellar ataxia 8 transcripts and suppresses neurodegeneration in Drosophila." 01/01/2006 - "However, recently it has been shown that toxic RNA species or disruption of RNA processing and metabolism may be partly to blame as clearly illustrated in spinal muscular atrophy, spinocerebellar ataxia 8 and fragile X-associated tremor/ataxia syndrome. "
3.	Untranslated Regions (Untranslated Region)IBA 09/01/2000 - "Spinocerebellar ataxia 8 (SCA8) is caused by a CTG repeat expansion in an untranslated region of a recently cloned gene on 13q21. "