Autosomal Dominant Lateral Temporal Lobe Epilepsy

Also Known As:

Autosomal dominant partial epilepsy with auditory features; Epilepsy, Lateral Temporal Lobe, Autosomal Dominant; Epilepsy, Partial, With Auditory Features

Networked: 29 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Related Diseases

1.	Glioma (Gliomas)
2.	Epilepsy (Aura)
3.	Autosomal Dominant Lateral Temporal Lobe Epilepsy
4.	Seizures (Absence Seizure)
5.	Partial Epilepsies (Epilepsy, Partial)

Experts

1.	Fukata, Masaki: 5 articles (03/2017 - 09/2006)
2.	Fukata, Yuko: 5 articles (03/2017 - 09/2006)
3.	Yokoi, Norihiko: 4 articles (03/2017 - 02/2010)
4.	Ikeda, Akio: 3 articles (02/2019 - 08/2012)
5.	Mashimo, Tomoji: 3 articles (02/2019 - 08/2012)
6.	Ohno, Yukihiro: 3 articles (02/2019 - 08/2012)
7.	Serikawa, Tadao: 3 articles (02/2019 - 08/2012)
8.	Takahashi, Ryosuke: 3 articles (02/2019 - 08/2012)
9.	Hu, Ping: 2 articles (01/2022 - 01/2022)
10.	Shi, Yun Stone: 2 articles (01/2022 - 01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Autosomal Dominant Lateral Temporal Lobe Epilepsy:

1.	Leucine (L-Leucine)FDA Link 01/01/2022 - "This study aimed to explore the pathomechanism of a mutation on the leucine-rich glioma inactivated 1 gene (LGI1) identified in a family having autosomal dominant lateral temporal lobe epilepsy (ADLTE), using a precise knock-in mouse model. " 07/01/2023 - "Leucine-rich glioma-inactivated 1 (LGI1) was identified as a causative gene of autosomal dominant lateral temporal lobe epilepsy. " 02/26/2019 - "Here, we analyzed the Kir4.1 expressional changes in Leucine-Rich Glioma-Inactivated 1 (Lgi1) mutant rats, which is a model of autosomal dominant lateral temporal lobe epilepsy in humans, to clarify the role of astrocytic Kir4.1 channels in Lgi1-related epileptogenesis. " 02/01/2015 - "Mutations in leucine-rich glioma inactivated 1 (LGI1) are linked to human autosomal dominant lateral temporal lobe epilepsy. " 06/01/2014 - "To clinically and genetically characterize a large Brazilian family with autosomal dominant partial epilepsy with auditory features (ADPEAF) not related to leucine-rich, glioma-inactivated 1 (LGI1) gene. "
2.	Proteins (Proteins, Gene)FDA Link 01/01/2015 - "Mutations in the human gene LGI1, encoding a neuronal secreted protein, cause autosomal dominant lateral temporal lobe epilepsy (ADLTE). " 11/13/2013 - "More than 30 mutations in LGI1, a secreted neuronal protein, have been reported with autosomal dominant lateral temporal lobe epilepsy (ADLTE). " 09/22/2006 - "However, one form of epilepsy, autosomal dominant partial epilepsy with auditory features (ADPEAF), is characterized by mutations in a secreted neuronal protein, LGI1. " 01/01/2022 - "Leucine-rich glioma-inactivated protein 1 (LGI1) is known to play a key role in autosomal dominant lateral temporal lobe epilepsy (ADLTE). " 12/01/2009 - "Most epilepsy genes encode ion channels, but the LGI1 gene responsible for autosomal dominant partial epilepsy with auditory features produces a secreted protein. "
3.	Ion Channels (Ion Channel)IBA 04/01/2004 - "Mutations in non-ion channel genes are responsible for autosomal-dominant lateral temporal lobe epilepsy, a form of idiopathic focal epilepsy, malformations of cortical development, and syndromes that combine X-linked mental retardation and epilepsy. " 12/01/2009 - "Most epilepsy genes encode ion channels, but the LGI1 gene responsible for autosomal dominant partial epilepsy with auditory features produces a secreted protein. " 01/01/2004 - "The two non-ion-channel genes, LGl1 causing autosomal dominant lateral temporal lobe epilepsy and MASS1 causing febrile and afebrile seizures, both contain a novel repeat motif variously called the epilepsy-associated repeat (EAR) and epitempin (EPTP) repeat. " 01/18/2012 - "Here we report that non-ion channel epilepsy gene LGI1 (leucine-rich glioma-inactivated), mutated in human autosomal dominant lateral temporal lobe epilepsy (ADLTE), regulates postnatal pruning of retinal axons in visual relay thalamus. "
4.	Retinaldehyde (Retinal)IBA 01/18/2012 - "Here we report that non-ion channel epilepsy gene LGI1 (leucine-rich glioma-inactivated), mutated in human autosomal dominant lateral temporal lobe epilepsy (ADLTE), regulates postnatal pruning of retinal axons in visual relay thalamus. "
5.	LigandsIBA 03/01/2017 - "Recent basic and clinical research has highlighted critical roles of a ligand-receptor complex, LGI1-ADAM22, in synaptic transmission and brain function, as mutations in the LGI1 gene cause autosomal dominant lateral temporal lobe epilepsy and autoantibodies to LGI1 cause limbic encephalitis which is characterized by memory loss and seizures. "
6.	Glycoproteins (Glycoprotein)IBA 10/20/2023 - "Leucine-rich Glioma Inactivated 1 (LGI1) is a glycoprotein secreted by neurons, the deletion of which leads to Autosomal Dominant Lateral Temporal Lobe Epilepsy. "
7.	AutoantibodiesIBA 03/01/2017 - "Recent basic and clinical research has highlighted critical roles of a ligand-receptor complex, LGI1-ADAM22, in synaptic transmission and brain function, as mutations in the LGI1 gene cause autosomal dominant lateral temporal lobe epilepsy and autoantibodies to LGI1 cause limbic encephalitis which is characterized by memory loss and seizures. "
8.	1- ethyl- 4- phenyl- 1,2,3,6- tetrahydropyridineIBA 01/01/2004 - "The two non-ion-channel genes, LGl1 causing autosomal dominant lateral temporal lobe epilepsy and MASS1 causing febrile and afebrile seizures, both contain a novel repeat motif variously called the epilepsy-associated repeat (EAR) and epitempin (EPTP) repeat. "