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Paraquat lung

Also Known As:
Paraquat induced lung disease
Networked: 10 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1. Fibrosis (Cirrhosis)
07/01/1994 - "The exponential nature of this finding suggested that the paraquat lung is a self-accelerating and therefore a malignant lesion, in contrast to the slowly progressing fibrosis that follows usual interstitial pneumonia. "
01/01/1978 - "The main features of the "paraquat lung" include haemorrhage, extrusion of macrophages, oedema, "honeycombing", fibrosis and, rarely, epithelial hyperplasia. "
03/01/1996 - "Pathological study of paraquat lung showed large variety of interstitial pneumonia and fibrosis, and morphometical analyses did not demonstrate structure-function correlation in paraquat dogs. "
01/01/1988 - "These observations suggest that: 1) preembedding immunohistochemical staining for elastin is localized in peripheral regions of normal elastic fibers because the antielastin antibody can penetrate into mature and undamaged amorphous components only to a very limited extent; 2) in early stages of paraquat toxicity this staining is more diffuse and intense because elastase from inflammatory cells partially degrades the elastic fibers and permits greater penetration of the antibody into the amorphous materials; 3) in later stages the staining pattern returns to normal as inflammation subsides and elastic fibers are repaired; however, newly formed elastic fibers in areas of intraalveolar fibrosis stain diffusely, reflecting increased penetration of the antibody because of immaturity and incomplete cross-linking, and 4) degeneration of elastic fibers of alveolar walls in paraquat lung may lead to alveolar dilatation, which is associated with irregular fibrosis and constitutes one of the processes of pulmonary structural remodeling in paraquat lung.(ABSTRACT TRUNCATED AT 250 WORDS)"
2. Interstitial Lung Diseases (Interstitial Lung Disease)
3. Wounds and Injuries (Trauma)
4. Pulmonary Fibrosis (Hamman Rich Syndrome)
5. Lung Injury

Related Drugs and Biologics

1. Paraquat
2. Vitamin E
3. Colchicine
4. Pancreatic Elastase (Elastase)
5. Elastin
6. Collagen