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Floating-harbor syndrome

A rare hereditary autosomal dominant disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips, Mutations in the SRCAP gene have been identified. OMIM: 136140
Also Known As:
FLHS; Leisti-Hollander-Rimoin Syndrome; Pelletier-Leisti syndrome
Networked: 78 relevant articles (4 outcomes, 14 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Fatty Liver
2. Hemorrhage
3. Inflammation (Inflammations)
4. Non-alcoholic Fatty Liver Disease
5. Floating-harbor syndrome

Experts

1. Hu, Guoliang: 8 articles (07/2021 - 10/2017)
2. Cao, Huabin: 6 articles (04/2020 - 10/2017)
3. Huang, Jianzhen: 5 articles (01/2021 - 10/2017)
4. Ruan, Jiming: 5 articles (01/2021 - 10/2017)
5. Guo, Xiaoquan: 4 articles (07/2021 - 05/2019)
6. Liu, Ping: 4 articles (07/2021 - 05/2019)
7. Zhang, Caiying: 4 articles (04/2020 - 05/2019)
8. Luo, Junrong: 4 articles (02/2020 - 10/2017)
9. Squires, E J: 4 articles (11/2008 - 09/2000)
10. Zhuang, Yu: 3 articles (07/2021 - 12/2019)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Floating-harbor syndrome:
1. LipidsIBA
2. Proteins (Proteins, Gene)FDA Link
3. LecithinsIBA
4. AntioxidantsIBA
5. ResveratrolIBA
6. Triglycerides (Triacylglycerol)IBA
12/01/2010 - "Fatty liver hemorrhagic syndrome (FLHS) is characterized by increased hepatic triacylglycerol content associated with liver hemorrhages and results in a sudden decline in egg production. "
09/01/2000 - "1. Two experiments were carried out to investigate the effect of dietary flaxseed, flax oil and n-3 fatty acid supplementation (Dry n-3) on hepatic fat content, plasma triglycerides, hepatic haemorrhage score, egg production, food intake and body weight in an inbred line of Single Comb White Leghorns (UCD-003) predisposed to fatty liver haemorrhagic syndrome (FLHS) and normal SCWL hens. "
02/01/2023 - "Among them, the proportions of phosphatidylserine (Control/FLHS, 33.1% vs. 29.1%), phosphatidylethanolamine (22.7% vs. 15.5%), phosphatidylcholine (15.7% vs. 11.7%) and phosphatidylinositol (7% vs. 6%) were reduced, while triacylglycerol (7.1% vs. 18.3%) and diglyceride (3.9% vs. 11.7%) were increased. "
09/01/2022 - "In addition, high-fat diet-induced FLHS hens had high levels of serum total cholesterol (TC), triglyceride (TG), alanine transaminase (ALT), and aspartate aminotransferase (AST) compared to the Con group, however, in the Model+SDS group, the levels of TC, TG, ALT, and AST decreased significantly, whereas the level of superoxide dismutase (SOD) increased significantly (P < 0.05). "
09/01/2021 - "Significant increased levels of alanine aminotransferase, aspartate aminotransferase, low density lipoprotein, total cholesterol and triglycerides, decreased high density lipoprotein (P < 0.01), and hepatic steatosis were observed in hens of FLHS group, which suggested FLHS was successfully established in this study. "
7. Estradiol (Delestrogen)FDA LinkGeneric
8. ChromatinIBA
9. CholesterolIBA
01/03/2023 - "Moreover, CLA inhibited hepatic de novo lipogenesis, cholesterol synthesis, and TG accumulation and increased TG hydrolysis in FLHS chickens by regulating related gene expression. "
01/03/2023 - "Mechanistically, CLA inhibited hepatic de novo lipogenesis, cholesterol synthesis, and TG accumulation and increased TG hydrolysis in FLHS chickens by regulating the gene expression of CD36, ACC, FAS, SCD 1, DGAT2, LIPE, ATGL, CPT1A, SREBP-1c, SREBP-2, PPARγ, and PPARα. "
09/01/2022 - "In addition, high-fat diet-induced FLHS hens had high levels of serum total cholesterol (TC), triglyceride (TG), alanine transaminase (ALT), and aspartate aminotransferase (AST) compared to the Con group, however, in the Model+SDS group, the levels of TC, TG, ALT, and AST decreased significantly, whereas the level of superoxide dismutase (SOD) increased significantly (P < 0.05). "
09/01/2021 - "Significant increased levels of alanine aminotransferase, aspartate aminotransferase, low density lipoprotein, total cholesterol and triglycerides, decreased high density lipoprotein (P < 0.01), and hepatic steatosis were observed in hens of FLHS group, which suggested FLHS was successfully established in this study. "
01/01/2022 - "ACD treatment ameliorated biochemical blood indicators in laying hens with FLHS by decreasing aspartate aminotransferase, alanine aminotransferase, triglycerides, low-density lipoprotein cholesterol, and total cholesterol, and increasing high-density lipoprotein cholesterol. "
10. Aspartate Aminotransferases (Aspartate Transaminase)IBA

Therapies and Procedures

1. Protein-Restricted Diet (Diet, Protein Restricted)
2. Intramuscular Injections
3. Therapeutics
4. Enteral Nutrition (Feeding, Tube)
5. Injections