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Flaujeac factor deficiency

Also Known As:
Fitzgerald Trait; HMWK Deficiency; High molecular weight kininogen deficiency; Kininogen Deficiency, High Molecular Weight; Kininogen Deficiency, Total
Networked: 35 relevant articles (0 outcomes, 3 trials/studies)

Disease Context: Research Results

Related Diseases

1. Factor XII Deficiency
2. Flaujeac factor deficiency
3. Prekallikrein Deficiency
4. Factor XI Deficiency (Hemophilia C)
5. Liver Cirrhosis (Hepatic Cirrhosis)

Experts

1. Fan, Liankai: 1 article (11/2020)
2. Qiao, Yacui: 1 article (11/2020)
3. Yang, Jing: 1 article (11/2020)
4. Zhao, Yongqiang: 1 article (11/2020)
5. Zhu, Tienan: 1 article (11/2020)
6. Conde, N: 1 article (02/2016)
7. Fernández-Teijeiro, A: 1 article (02/2016)
8. García Aldana, D: 1 article (02/2016)
9. Romero, I: 1 article (02/2016)
10. Ruano, A: 1 article (02/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Flaujeac factor deficiency:
1. Kininogens (Kininogen)IBA
2. Factor XI (Plasma Thromboplastin Antecedent)IBA
3. Proteins (Proteins, Gene)FDA Link
4. AntigensIBA
5. High-Molecular-Weight Kininogen (Kininogen, High Molecular Weight)IBA
6. PrekallikreinIBA
7. Low-Molecular-Weight Kininogen (Kininogen, Low Molecular Weight)IBA
8. KininsIBA
07/01/1982 - "In the three subjects with Fletcher trait, blood kinins were 16, 21, and 31 pg/ml, whereas in the subject with Fitzgerald trait they were 26 pg/ml. Normal subjects had concentrations in the same range (9 to 55 pg/ml), indicating that the concentration of blood kinins in normal subjects is much lower than previously reported (70 to 5000 pg/ml). "
05/01/1975 - "Fitzgerald Trait: Deficiency of a Hitherto Unrecognized Agent, Fitzgerald Factor, Participating in Surface-Mediated Reactions of Clotting, Fibrinolysis, Generation of Kinins, and the Property of Diluted Plasma Enhancing Vascular Permeability (PF/Dil)."
02/01/1976 - "The coagulation defect was identified as "Fitzgerald trait." A preparation of high molecular weight kininogen repaired the defects in clotting, kinin release and fibrinolysis, but a preparation of low molecular weight kininogen did not. "
02/01/1976 - "Fitzgerald trait, an asymptomatic disorder, is associated with abnormalities of surface-mediated plasma reactions, including coagulation via the intrinsic pathway, augmentation of the clot-promoting properties of factor VII, kaolin-mediated fibrinolysis, kinin generation, and enhancement of vascular permeability by diluted plasma (PF/Dil). "
07/01/1982 - "To determine whether the circulating kinins are formed by plasma kallikrein or other kininogenases, the concentration of blood kinins was measured in the venous blood of three patients with congenital deficiency in plasma prekallikrein (Fletcher trait) and in one patient with congenital deficiency in the substrate of plasma kallikrein, high-molecular-weight kininogen (Fitzgerald trait). "
9. KaolinIBA
10. Blood Coagulation Factors (Coagulation Factor)IBA