TARP syndrome

TARPS=Talipes equinovarus, atrial septal defect, robin sequence, and persistence of left superior vena cava

Also Known As:

Pierre Robin syndrome with congenital heart malformation and clubfoot; Talipes Equinovarus, Atrial Septal Defect, Robin Sequence, and Persistence of Left Superior Vena Cava

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Musculoskeletal Diseases: 719
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Congenital Abnormalities: 25723
Cardiovascular Diseases: 91362
- Heart Diseases: 26014
  - Congenital Heart Defects: 8917
    - TARP syndrome: 8
- Cardiovascular Abnormalities: 452
  - Congenital Heart Defects: 8917
    - TARP syndrome: 8
Stomatognathic Diseases: 705
- Jaw Diseases: 15
  - Jaw Abnormalities: 10
    - Pierre Robin Syndrome: 349
      - TARP syndrome: 8
- Stomatognathic System Abnormalities
  - Maxillofacial Abnormalities: 10
    - Jaw Abnormalities: 10
      - Pierre Robin Syndrome: 349
        TARP syndrome: 8

Related Diseases

1.	Intestinal Volvulus (Volvulus)
2.	Tetralogy of Fallot (Fallot Tetralogy)
3.	Tachycardia (Tachyarrhythmias)
4.	Cleft Palate (Palate, Cleft)
5.	Adenocarcinoma of Lung

Experts

1.	Chen, Wei: 2 articles (01/2021 - 08/2017)
2.	Al-Qattan, Mohammad M: 1 article (04/2022)
3.	Almohrij, Saad A: 1 article (04/2022)
4.	Manotas, Hernan: 1 article (05/2021)
5.	Payán-Gómez, César: 1 article (05/2021)
6.	Piñeros, Juan Gabriel: 1 article (05/2021)
7.	Roa, Maria Fernanda: 1 article (05/2021)
8.	Ban, Hyoju: 1 article (01/2021)
9.	Gao, Qingsong: 1 article (01/2021)
10.	He, Haijin: 1 article (01/2021)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to TARP syndrome:

1.	RNA Splicing FactorsIBA 01/01/2021 - "In this study, we identified a fission yeast homologue of human splicing factor RBM10, which has been linked to TARP syndrome. "
2.	RNA-Binding Proteins (RNA-Binding Protein)IBA 08/21/2017 - "Mutations in the spliceosomal RNA binding protein RBM10 cause TARP syndrome and are frequently observed in lung adenocarcinoma (LUAD). " 01/01/2017 - "Mutations in the RNA-binding protein, RBM10, result in a human syndromic form of cleft palate, termed TARP syndrome. " 04/01/2022 - "These included interactions with collagen type II (in Strickler syndrome), exon junction complex (in Richier-Costa-Periera syndrome), glucose (in Catel-Manzke syndrome), RNA-binding proteins (in TARP syndrome), and the spliceosome (in cerebra-costo-mandibular syndrome). "
3.	Collagen Type II (Type II Collagen)IBA 04/01/2022 - "These included interactions with collagen type II (in Strickler syndrome), exon junction complex (in Richier-Costa-Periera syndrome), glucose (in Catel-Manzke syndrome), RNA-binding proteins (in TARP syndrome), and the spliceosome (in cerebra-costo-mandibular syndrome). "
4.	RNA (Ribonucleic Acid)IBA 01/01/2017 - "To uncover the cellular functions of RBM10 in a cell line that is relevant to the phenotype observed in TARP syndrome, we used iCLIP to identify its endogenous RNA targets in a mouse embryonic mandibular cell line. "
5.	Proteins (Proteins, Gene)FDA Link 05/24/2021 - "Here, we report on a patient with TARP syndrome and a previously unreported mutation, c.1877del; p.his627Leufs*78, which is predicted to generate a truncated and/or protein decay of the RBM10 transcript."
6.	Glucose (Dextrose)FDA LinkGeneric 04/01/2022 - "These included interactions with collagen type II (in Strickler syndrome), exon junction complex (in Richier-Costa-Periera syndrome), glucose (in Catel-Manzke syndrome), RNA-binding proteins (in TARP syndrome), and the spliceosome (in cerebra-costo-mandibular syndrome). "
7.	alpha-Fetoproteins (alpha-Fetoprotein)IBA 03/21/2023 - "During infancy, he had an extremely high alpha-fetoprotein, conjugated hyperbilirubinaemia and thrombocytopaenia, features not previously described in TARP syndrome. "
8.	TARPIBA 12/01/2018 - "The patient also had physical findings common with previously reported individuals with TARP syndrome in the literature but not described by the TARP acronym. "
9.	landiololIBA 08/01/2018 - "Efficacy and safety of cardioversion with continuous landiolol infusion for atrial tachyarrhythmia in an inflammatory state caused by volvulus in a child with TARP syndrome and postoperative tetralogy of Fallot."

Therapies and Procedures

1.	Electric Countershock (Cardioversion) 08/01/2018 - "Efficacy and safety of cardioversion with continuous landiolol infusion for atrial tachyarrhythmia in an inflammatory state caused by volvulus in a child with TARP syndrome and postoperative tetralogy of Fallot."