Wells syndrome

A rare type of eosinophilia that primarily affects the skin. It is characterized by a skin rash that is often proceeded by an itching or burning sensation. The rash may persist for 4 to 8 weeks and can recur years later.

Also Known As:

Bullous cellulitis with eosinophilia; Eosinophilic cellulitis; Wells' syndrome

Networked: 103 relevant articles (10 outcomes, 1 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Wells syndrome
2.	Neoplasms (Cancer)
3.	Hearing Loss (Hearing Impairment)
4.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
5.	Churg-Strauss Syndrome (Allergic Angiitis)

Experts

1.	Junkins-Hopkins, Jacqueline M: 2 articles (08/2022 - 12/2003)
2.	Yamamoto, Toshiyuki: 2 articles (11/2020 - 03/2020)
3.	Simon, Dagmar: 2 articles (01/2011 - 04/2003)
4.	Simon, Hans-Uwe: 2 articles (01/2011 - 04/2003)
5.	Kaufmann, Roland: 2 articles (07/2005 - 05/2003)
6.	Ludwig, Ralf J: 2 articles (07/2005 - 05/2003)
7.	Wolter, Manfred: 2 articles (07/2005 - 05/2003)
8.	Zollner, Thomas M: 2 articles (07/2005 - 05/2003)
9.	Bleicher, Isaac D: 1 article (11/2022)
10.	Reshef, Edith R: 1 article (11/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Wells syndrome:

1.	mepolizumabIBA 07/01/2020 - "Effective treatment with mepolizumab in a patient with refractory Wells syndrome." 11/01/2022 - "Mepolizumab is highly effective in a rare case of Wells syndrome: Eosinophilic granulomatosis with polyangiitis overlap." 07/01/2018 - "Eosinophilic cellulitis (Wells syndrome) successfully treated with mepolizumab." 04/01/2022 - "Idiopathic hypereosinophilic syndrome with eosinophilic cellulitis-like cutaneous involvement treated with mepolizumab and dapsone."
2.	Omalizumab (Xolair)FDA Link 01/01/2020 - "Long-term Remission of Wells Syndrome With Omalizumab." 08/01/2018 - "Wells syndrome: a case of successful treatment with omalizumab." 10/01/2019 - "Wells syndrome and chronic spontaneous urticaria: report of four cases successfully treated with omalizumab."
3.	dupilumabIBA 06/01/2023 - "Atypical Wells syndrome successfully treated with dupilumab." 01/01/2023 - "Wells syndrome successfully treated with dupilumab." 11/01/2021 - "Dupilumab in eosinophilic cellulitis (Wells' syndrome) - case report of a potential new treatment option." 06/01/2023 - "Here, we report a unique case of progressively worsening neutrophilic-rich Wells syndrome on the vertex of the scalp that was successfully treated with a combination of dupilumab and oral corticosteroids."
4.	Metronidazole (Metric)FDA LinkGeneric 08/31/2021 - "She was successfully treated for Clostridioides difficile with metronidazole and probiotics, and had complete clinical remission of the Wells syndrome with mometasone furoate cream and levocetirizine. "
5.	GlycosidesIBA 01/01/2021 - "Our case suggests that tripterygium glycosides may be a safe and effective treatment option for Wells syndrome." 01/01/2021 - "Wells Syndrome Successfully Treated with Tripterygium Glycosides."
6.	Cortisone FDA Link 01/01/2018 - "Wells syndrome (eosinophilic cellulitis) caused by adrenal insufficiency and relieved by cortisone supplementation."
7.	Antiviral Agents (Antivirals)IBA 05/01/2003 - "Antiviral therapy led to a complete remission of eosinophilic cellulitis, indicating that causative treatment of underlying diseases can be effective in controlling eosinophilic cellulitis."
8.	Mometasone Furoate (Nasonex)FDA LinkGeneric 08/31/2021 - "She was successfully treated for Clostridioides difficile with metronidazole and probiotics, and had complete clinical remission of the Wells syndrome with mometasone furoate cream and levocetirizine. "
9.	levocetirizine FDA LinkGeneric 08/31/2021 - "She was successfully treated for Clostridioides difficile with metronidazole and probiotics, and had complete clinical remission of the Wells syndrome with mometasone furoate cream and levocetirizine. "
10.	Antigen-Antibody Complex (Immune Complex)IBA 09/01/1990 - "The etiopathogenesis of the disease is discussed as is the possible role of immune complexes in eosinophilic cellulitis." 01/01/1988 - "Eosinophilic cellulitis (Wells' syndrome): ultrastructural study of a case with circulating immune complexes." 02/01/1986 - "Significant associated diseases included psychiatric illness, 6 (drug dependency, 4); atopy, 5 (asthma, 3); malignancies, 5; immune complex vasculitis, 4; thyroid disease, 2; Wells' eosinophilic cellulitis, 2; glomerulonephritis and sarcoidosis, 1 each. " 01/01/2022 - "A focus on its main differential diagnoses is provided, that is, chronic spontaneous urticaria, bullous pemphigoid, IgA (Henoch-Schönlein purpura) and IgM/IgG immune complex vasculitis, lupus erythematous tumidus, Wells syndrome, erythema multiforme, cutaneous mastocytosis, cryopyrin-associated periodic syndromes, and coronavirus disease 2019-associated and anti-severe acute respiratory syndrome coronavirus 2-vaccine-associated urticarial eruptions."

Therapies and Procedures

1.	Therapeutics 11/01/2010 - "[Diagnosis and therapy of a dog with an atypical eosinophilic cellulitis]." 06/01/2012 - "Wells syndrome is an inflammatory eosinophilic dermatosis of unknown pathogenesis characterized by clinical polymorphism, a suggestive but nonspecific histopathologic traits, usually with a recurrent course and inconstant response to therapy. " 05/01/2003 - "Antiviral therapy led to a complete remission of eosinophilic cellulitis, indicating that causative treatment of underlying diseases can be effective in controlling eosinophilic cellulitis." 12/01/2020 - "This case highlights the various clinical forms that Wells syndrome may present with and may serve as a good example for the use of Luna stain as a simple and cost-effective diagnostic tool that can help to arrive at the accurate diagnosis and inform therapy." 08/01/2014 - "Wells syndrome: response to dapsone therapy."
2.	Drug Therapy (Chemotherapy) 01/01/2007 - "The typical skin findings of Wells' syndrome disappeared completely following chemotherapy and autologous stem cell transplantation." 01/01/2019 - "Is chemotherapy the best option for chronic lymphocytic leukemia associated Wells' syndrome? "
3.	Cochlear Implantation 12/01/2019 - "The Long-Term Efficacy of Cochlear Implantation for Hearing Loss in Muckel-Wells Syndrome."
4.	Colectomy 07/01/2005 - "Curative hemicolectomy led to a complete remission, suggesting that underlying malignancies can trigger eosinophilic cellulitis."
5.	Tattooing 08/01/2022 - "Here we present the first case of a permanent tattoo with resulting flame figures, histologically resembling Wells syndrome. " 08/01/2022 - "To date, there has been one case report of a Wells syndrome-like inflammatory pattern associated with a temporary Henna tattoo. " 08/01/2022 - "Wells Syndrome-Like Histologic Pattern Caused by a Permanent Tattoo." 10/01/2014 - "Eosinophilic cellulitis (Wells' syndrome) caused by a temporary henna tattoo." 10/01/2014 - "Here, a 9-year-old male patient with Wells' syndrome is presented, which developed following a temporary henna tattoo and shown by the patch test sensitivity to paraphenylenediamine. "