Familial dermographism

Also Known As:

Dermatographism, Familial; Dermo-distortive urticaria; Dermodistortive Urticaria; Dermographism, Familial; Familial dermatographism; dermatographia; dermographic urticaria; dermographism; familial dermatographia; familial dermographic urticaria; symptomatic dermographism; urticaria factitia

Networked: 131 relevant articles (6 outcomes, 12 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Erythema
2.	Urticaria (Hives)
3.	Cold Urticaria
4.	Chronic Inducible Urticaria
5.	Chronic Urticaria

Experts

1.	Maurer, Marcus: 7 articles (01/2022 - 01/2011)
2.	Metz, Martin: 4 articles (01/2018 - 01/2011)
3.	Staubach, Petra: 3 articles (01/2022 - 01/2017)
4.	Maurer, M: 3 articles (11/2019 - 07/2009)
5.	Magerl, M: 3 articles (06/2015 - 07/2009)
6.	Zuberbier, T: 3 articles (11/2010 - 10/2000)
7.	Chen, Xiang: 2 articles (02/2022 - 01/2021)
8.	Altrichter, Sabine: 2 articles (01/2022 - 01/2011)
9.	Siebenhaar, Frank: 2 articles (01/2022 - 01/2011)
10.	Ayala, F: 2 articles (04/2018 - 06/2000)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Familial dermographism:

1.	Histamine Antagonists (Antihistamines)IBA 11/01/2008 - "The apparent rarity of antihistamine-resistant symptomatic dermographism limited the study to a small number of participants. " 07/01/1979 - "The effect of H1 and H2 histamine antagonists on symptomatic dermographism." 11/01/2008 - "Narrowband ultraviolet B phototherapy is beneficial in antihistamine-resistant symptomatic dermographism: a pilot study." 03/01/2003 - "All patients with reactions to topical products due to dermographism improved with counseling and antihistamine therapy. " 06/01/2000 - "In our series: 1. SU affects both sexes usually when they are under 30 years of age; 2. nearly half the patients are free of disease within 5 years; 3. in about one fourth of cases SU is associated with dermographic urticaria or displays a history of atopic dermatitis; 4. the wheals are elicited mainly by VIS or UVA; 5. SU can be prevented, at least in part, by antihistamines or by PUVA therapy."
2.	Omalizumab (Xolair)FDA Link 01/01/2017 - "Omalizumab is effective in symptomatic dermographism-results of a randomized placebo-controlled trial." 01/01/2023 - "There are few studies in the literature evaluating omalizumab treatment response in patients with symptomatic dermographism (SDerm). " 01/01/2022 - "A total of 45 patients were enrolled in 4 cohorts (n = 13 omalizumab-naive CSU, n = 11 omalizumab-refractory CSU, n = 11 CholU, n = 10 symptomatic dermographism). " 11/01/2020 - "Successful treatment of symptomatic dermographism in an adolescent with omalizumab." 08/01/2019 - "The urticaria factitia patient showed no benefit of the add-on 5 months treatment with omalizumab. "
3.	Histamine (Histamine Dihydrochloride)FDA Link 01/01/1949 - "The effect of antihistaminics on histamine whealing and on dermographism; elucidated by comparative electrophoretical experiments." 04/01/1985 - "Since the degree of residual dermographism was comparable despite great differences in histamine weal inhibition a vasoactive mechanism in addition to that mediated by histamine must be involved in dermographic urticaria." 12/01/2006 - "This is manifested by white dermographism, an irregular vascular response to thermal stimuli, and paradoxic skin reactions to histamine, cholinergic agents, and nicotinates. " 11/01/1989 - "Symptomatic dermographism: wealing, mast cells and histamine are decreased in the skin following long-term application of a potent topical corticosteroid." 04/29/1949 - "Influence of antihistamine on histamine papules and urticariat dermographism."
4.	Adrenal Cortex Hormones (Corticosteroids)IBA 06/01/2010 - "Exclusion criteria comprised the presence of dermographism, physical urticaria, urticarial vasculitis, and failure to discontinue anti-H1 drugs or corticosteroids. " 03/01/2002 - "We evaluated the role of corticosteroids and cyclophosphamide in the treatment of chronic dermographic urticaria. " 11/01/1989 - "Symptomatic dermographism: wealing, mast cells and histamine are decreased in the skin following long-term application of a potent topical corticosteroid." 03/01/2002 - "Efficacy of H, antihistamine, corticosteroids and cyclophosphamide in the treatment of chronic dermographic urticaria."
5.	Substance PIBA 03/01/1996 - "Erythema of the dermographic test sites was always significantly greater (P < 0.001) in the group with urticarial dermographism at 2, 4, and 8 min, and cutaneous reactivity with titrated prick tests was significantly increased in this group with low concentrations of histamine, 0.01% and substance P (0.25 mM) (P < 0.05). " 01/01/1987 - "Occurrence of substance P, vasoactive intestinal peptide, and calcitonin gene-related peptide in dermographism and cold urticaria." 01/01/1987 - "Substance P (SP), calcitonin gene-related peptide (CGRP), and vasoactive intestinal peptide (VIP) were assayed in lesions and normal skin of patients with dermographism and cold urticaria utilizing suction-induced blisters. "
6.	Cyclophosphamide (Cytoxan)FDA LinkGeneric 03/01/2002 - "We evaluated the role of corticosteroids and cyclophosphamide in the treatment of chronic dermographic urticaria. " 03/01/2002 - "Efficacy of H, antihistamine, corticosteroids and cyclophosphamide in the treatment of chronic dermographic urticaria."
7.	Cholinergic Agents (Cholinergics)IBA 09/01/1986 - "Cholinergic dermographism." 01/01/2020 - "Most had dermographic urticaria (70.3%), followed by cholinergic urticaria (17.8%). " 05/01/1994 - "Two forms, dermographism and cholinergic urticaria, are quite common and represent more than two-thirds of all cases of physically caused urticaria. " 12/01/1993 - "One hundred thirty-five patients were tested for immediate dermographism, for DPU and, when indicated by the history, for cholinergic and/or cold urticaria. " 01/01/1983 - "17 patients had physical urticaria, cold (6), pressure (5), delayed dermographism (1), cholinergic (4), solar (1). "
8.	Chlorpheniramine (Chlorphenamine)FDA LinkGeneric 04/01/1985 - "The effects of the H I receptor antagonists astemizole and chlorpheniramine on dermographism were compared in a double-blind study in sixteen patients. " 04/01/1985 - "A comparison of astemizole and chlorpheniramine in dermographic urticaria." 07/01/1979 - "In ten patients suffering from symptomatic dermographism the combined administration of chlorpheniramine + cimetidine produced a greater reduction in the weal and flare response provoked by a standardized scratch than the administration of chlorpheniramine alone. " 03/01/1973 - "Dermographism: reduction in weal size by chlorpheniramine and hydroxyzine." 02/01/1981 - "Factitious urticaria (dermographism): treatment by cimetidine and chlorpheniramine in a randomized double-blind study."
9.	Terfenadine (Seldane)IBA 01/01/1989 - "Acrivastine versus terfenadine in the treatment of symptomatic dermographism--a double-blind, placebo-controlled study." 01/01/1986 - "Brompheniramine maleate was more effective than terfenadine in the patients with dermographism." 01/01/1986 - "The effects of brompheniramine maleate (12 mg twice daily in sustained release form) and terfenadine (60 mg twice daily) on the symptoms and well-being of 16 adults with urticaria with or without dermographism were assessed by symptom questionnaire. " 01/01/1986 - "Terfenadine and brompheniramine maleate in urticaria and dermographism."
10.	Codeine (Codeine Phosphate)FDA LinkGeneric 05/01/2013 - "Although, codeine was among the safest alternative drugs and none of the patients had an anaphylactic reaction to it, thus a challenge with codeine may be considered especially in patients with dermographism. " 11/01/1992 - "This study examined cutaneous mast cell behaviour in 14 patients with chronic urticaria but no dermographism and 11 healthy controls, by measuring cutaneous weal and flare reactions evoked in response to intradermal challenge injections of 0.1 ml isotonic saline, histamine (20 micrograms), codeine phosphate (10 micrograms) and compound 48/80 (10 micrograms). "

Therapies and Procedures

1.	Therapeutics 06/01/2015 - "Symptomatic dermographism is a common urticarial condition, which requires determination of provocation thresholds to confirm diagnosis and allow physicians to individualize management and therapy for optimal control of symptoms. " 11/01/2008 - "We sought to examine the clinical efficacy of NB UVB therapy for itch and whealing in symptomatic dermographism and to assess the duration of the effect during 3 months of follow-up. " 09/01/1983 - "Symptomatic dermographism: natural history, clinical features laboratory investigations and response to therapy." 03/01/1956 - "[Effects of autonomic-vascular therapy on dermographism]." 03/01/2003 - "All patients with reactions to topical products due to dermographism improved with counseling and antihistamine therapy. "
2.	Phototherapy (Light Therapy) 11/01/2008 - "Narrowband ultraviolet B phototherapy is beneficial in antihistamine-resistant symptomatic dermographism: a pilot study." 11/01/2008 - "NB UVB phototherapy is an effective second-line treatment for patients with severe symptomatic dermographism responding poorly to fexofenadine. "
3.	Injections 11/01/1992 - "This study examined cutaneous mast cell behaviour in 14 patients with chronic urticaria but no dermographism and 11 healthy controls, by measuring cutaneous weal and flare reactions evoked in response to intradermal challenge injections of 0.1 ml isotonic saline, histamine (20 micrograms), codeine phosphate (10 micrograms) and compound 48/80 (10 micrograms). "
4.	Photochemotherapy (Photodynamic Therapy) 01/01/1989 - "The effect of psoralen photochemotherapy (PUVA) on symptomatic dermographism." 11/01/2008 - "Photochemotherapy (psoralen plus ultraviolet [UV] A) may help the itch of dermographism but the effect of narrowband (NB) UVB therapy has not been previously studied. "
5.	Aftercare (After-Treatment) 12/01/1987 - "The dermographism test was negative or considerably reduced after treatment. " 01/01/1984 - "Dermographism relapsed towards its pre-treatment state during the 3 days after treatment was stopped. "