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Thiopurine S methyltranferase deficiency

An increased sensitivity to 6-Mercaptopurine due to mutations in thiopurine methyltransferase that results in decreased enzyme activity.
Also Known As:
6 alpha mercaptopurine sensitivity; TPMT deficiency; Thiopurine methyltransferase deficiency; Thiopurines, poor metabolism of
Networked: 23 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Barclay, Murray L: 3 articles (10/2012 - 01/2006)
2. Gardiner, Sharon J: 2 articles (10/2006 - 01/2006)
3. Gearry, Richard B: 2 articles (10/2006 - 01/2006)
4. Begg, Evan J: 2 articles (10/2006 - 01/2006)
5. Hindorf, U: 2 articles (10/2006 - 01/2003)
6. Schwab, M: 2 articles (01/2003 - 08/2001)
7. Schaeffeler, E: 2 articles (01/2003 - 08/2001)
8. Eichelbaum, M: 2 articles (01/2003 - 08/2001)
9. Roberts, Rebecca L: 1 article (10/2012)
10. Dewit, O: 1 article (09/2011)

Related Diseases

1. Crohn Disease (Crohn's Disease)
2. Body Weight (Weight, Body)
3. Pancytopenia
4. Leukopenia
5. Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)

Related Drugs and Biologics

1. Azathioprine (Imuran)
2. tranilast (N 5')
3. 6-Mercaptopurine (Mercaptopurine)
4. thiopurine methyltransferase (thiopurine S-methyltransferase)
5. Transferases
6. Thioguanine (Tioguanine)
7. azathiopurine

Related Therapies and Procedures

1. Immunomodulation
2. Kidney Transplantation