Cleft palate X-linked

Also Known As:

Cleft Palate, X-Linked; X-linked cleft palate

Networked: 18 relevant articles (0 outcomes, 1 trials/studies)

Disease Context: Research Results

Musculoskeletal Diseases: 719
- Musculoskeletal Abnormalities: 43
  - Craniofacial Abnormalities: 203
    - Maxillofacial Abnormalities: 10
      - Jaw Abnormalities: 10
        Cleft Palate: 2757
        Cleft palate X-linked: 18
- Jaw Diseases: 15
  - Jaw Abnormalities: 10
    - Cleft Palate: 2757
      - Cleft palate X-linked: 18
Stomatognathic Diseases: 705
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Congenital Abnormalities: 25723
  - Musculoskeletal Abnormalities: 43
    - Craniofacial Abnormalities: 203
      - Maxillofacial Abnormalities: 10
        Jaw Abnormalities: 10
        Cleft Palate: 2757
        Cleft palate X-linked: 18
  - Stomatognathic System Abnormalities
    - Maxillofacial Abnormalities: 10
      - Jaw Abnormalities: 10
        Cleft Palate: 2757
        Cleft palate X-linked: 18
    - Mouth Abnormalities: 1
      - Cleft Palate: 2757
        Cleft palate X-linked: 18
- Inborn Genetic Diseases: 11939
  - X-Linked Genetic Diseases: 42
    - Cleft palate X-linked: 18

Related Diseases

1.	Ankyloglossia
2.	Pterygium
3.	Zlotogora-Ogur syndrome
4.	Cleft Palate (Palate, Cleft)
5.	Cleft Lip (Harelip)

Experts

1.	Stanier, P: 5 articles (04/2013 - 10/2001)
2.	Moore, G E: 4 articles (04/2013 - 10/2001)
3.	Pauws, E: 3 articles (04/2013 - 08/2009)
4.	Hoshino, A: 2 articles (04/2013 - 04/2011)
5.	Lees, M: 2 articles (04/2013 - 04/2011)
6.	Doudney, K: 2 articles (02/2010 - 10/2001)
7.	Moore, Gudrun E: 2 articles (11/2009 - 10/2007)
8.	Pauws, Erwin: 2 articles (11/2009 - 10/2007)
9.	Stanier, Philip: 2 articles (11/2009 - 10/2007)
10.	Askarian, Saeedeh: 1 article (04/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Cleft palate X-linked:

1.	Genetic Markers (Genetic Marker)IBA 04/01/1988 - "X-linked cleft palate: the gene is localized between polymorphic DNA markers DXYS12 and DXS17." 08/01/1994 - "A locus (CPX) responsible for X-linked cleft palate and ankyloglossia was previously mapped to the proximal long arm of the X chromosome through DNA marker linkage studies in two large kindred: an Icelandic family and a British Columbia (B.C.) Native family. "
2.	Transcription Factors (Transcription Factor)IBA 12/01/2018 - "Mutations in the T-Box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome). " 01/01/2018 - "Mutations in the gene encoding the transcription factor TBX22 have been involved in isolated ankyloglossia and X-linked cleft palate. " 10/01/2015 - "TBX22 encodes a T-box containing transcription factor and mutations in this gene are responsible for X-linked cleft palate and ankyloglossia. " 04/01/2011 - "X-linked cleft palate and ankyloglossia (CPX) are caused by mutations in the TBX22 transcription factor. " 11/01/2010 - "Mutations in the gene encoding the T-box transcription factor TBX22 cause X-linked cleft palate and ankyloglossia in humans. "
3.	InterferonsIBA 06/01/2023 - "There is a growing body of data illustrating the association of several genes with risk of developing this malformation, including genetic defects in T-box transcription factor-22 (TBX22), interferon regulatory factor-6 (IRF6), and poliovirus receptor-like-1 (PVRL1), responsible for X-linked cleft palate, cleft lip/palate-ectodermal dysplasia syndrome, and Van der Woude and popliteal pterygium syndromes, respectively. " 01/01/2012 - "Three of them-T-box transcription factor-22 (TBX22), poliovirus receptor-like-1 (PVRL1), and interferon regulatory factor-6 (IRF6)-are responsible for causing X-linked cleft palate, cleft lip/palate-ectodermal dysplasia syndrome, and Van der Woude and popliteal pterygium syndromes, respectively; they are also implicated in nonsyndromic CLP. " 10/01/2004 - "Three of them--namely T-box transcription factor-22 (TBX22), poliovirus receptor like-1 (PVRL1), and interferon regulatory factor-6 (IRF6)--are responsible for causing X-linked cleft palate, cleft lip/palate-ectodermal dysplasia syndrome, and Van der Woude's and popliteal pterygium syndromes, respectively; they are also implied in non-syndromic cleft lip and palate. "
4.	NectinsIBA 06/01/2023 - "There is a growing body of data illustrating the association of several genes with risk of developing this malformation, including genetic defects in T-box transcription factor-22 (TBX22), interferon regulatory factor-6 (IRF6), and poliovirus receptor-like-1 (PVRL1), responsible for X-linked cleft palate, cleft lip/palate-ectodermal dysplasia syndrome, and Van der Woude and popliteal pterygium syndromes, respectively. " 01/01/2012 - "Three of them-T-box transcription factor-22 (TBX22), poliovirus receptor-like-1 (PVRL1), and interferon regulatory factor-6 (IRF6)-are responsible for causing X-linked cleft palate, cleft lip/palate-ectodermal dysplasia syndrome, and Van der Woude and popliteal pterygium syndromes, respectively; they are also implicated in nonsyndromic CLP. " 10/01/2004 - "Three of them--namely T-box transcription factor-22 (TBX22), poliovirus receptor like-1 (PVRL1), and interferon regulatory factor-6 (IRF6)--are responsible for causing X-linked cleft palate, cleft lip/palate-ectodermal dysplasia syndrome, and Van der Woude's and popliteal pterygium syndromes, respectively; they are also implied in non-syndromic cleft lip and palate. "
5.	DNA (Deoxyribonucleic Acid)IBA 06/19/2019 - "TBX22 (Chr X: 107667964-107688978) functioning as a transcriptional repressor affects DNA binding, sumoylation, and transcriptional repression associated with X-linked cleft palate. " 10/01/2007 - "TBX22 missense mutations found in patients with X-linked cleft palate affect DNA binding, sumoylation, and transcriptional repression."
6.	poliovirus receptorIBA 10/01/2004 - "Three of them--namely T-box transcription factor-22 (TBX22), poliovirus receptor like-1 (PVRL1), and interferon regulatory factor-6 (IRF6)--are responsible for causing X-linked cleft palate, cleft lip/palate-ectodermal dysplasia syndrome, and Van der Woude's and popliteal pterygium syndromes, respectively; they are also implied in non-syndromic cleft lip and palate. "