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Primary lateral sclerosis juvenile

Also Known As:

Juvenile Primary Lateral Sclerosis; Primary Lateral Sclerosis, Juvenile

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Nervous System Diseases: 14178
- Neurodegenerative Diseases: 42472
  - Motor Neuron Disease: 1823
    - Primary lateral sclerosis juvenile: 3
- Neuromuscular Diseases: 2005
  - Motor Neuron Disease: 1823
    - Primary lateral sclerosis juvenile: 3

Related Diseases

1.	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease)
2.	infantile onset ascending Hereditary spastic paralysis
3.	Motor Neuron Disease (Primary Lateral Sclerosis)
4.	Juvenile Amyotrophic Lateral Sclerosis 2
5.	Neurodegenerative Diseases (Neurodegenerative Disease)

Experts

1.	Boccardo, Marta: 1 article (01/2022)
2.	Casaluci, Rossana Rita: 1 article (01/2022)
3.	Cavaglià, Marco: 1 article (01/2022)
4.	Ceccarelli, Noemi: 1 article (01/2022)
5.	De Maio, Alessandra: 1 article (01/2022)
6.	Deriu, Marco A: 1 article (01/2022)
7.	Exertier, Cécile: 1 article (01/2022)
8.	Gugole, Elena: 1 article (01/2022)
9.	Miceli, Marcello: 1 article (01/2022)
10.	Vallone, Beatrice: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Primary lateral sclerosis juvenile:

1.	Proteins (Proteins, Gene)FDA Link 01/01/2022 - "We focus on Alsin, a protein responsible for rare motor neuron diseases, such as infantile-onset ascending hereditary spastic paralysis (IAHSP) and juvenile primary lateral sclerosis (JPLS), and involved in some cases of amyotrophic lateral sclerosis (ALS). " 01/05/2022 - "Infantile-onset Ascending Hereditary Spastic Paralysis, Juvenile Primary Lateral Sclerosis and Juvenile Amyotrophic Lateral Sclerosis are all motor neuron diseases related to mutations on the ALS2 gene, encoding for a 1657 amino acids protein named Alsin. "
2.	Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)IBA 11/01/2018 - "Biallelic mutations of the alsin Rho guanine nucleotide exchange factor (ALS2) gene cause a group of overlapping autosomal recessive neurodegenerative disorders including infantile-onset ascending hereditary spastic paralysis (IAHSP), juvenile primary lateral sclerosis (JPLS), and juvenile amyotrophic lateral sclerosis (JALS/ALS2), caused by retrograde degeneration of the upper motor neurons of the pyramidal tracts. "
3.	Amino Acids FDA Link 01/05/2022 - "Infantile-onset Ascending Hereditary Spastic Paralysis, Juvenile Primary Lateral Sclerosis and Juvenile Amyotrophic Lateral Sclerosis are all motor neuron diseases related to mutations on the ALS2 gene, encoding for a 1657 amino acids protein named Alsin. "