Angiostrongyliasis

Infection by nematode larvae of the ANGIOSTRONGYLUS genus, particularly of the gatrointestinal tract or MENINGES, which may cause eosinophilic meningitis.

Also Known As:

Abdominal angiostrongyliasis; Angiostrongylus cantonensis infection; Angiostrongylus costaricensis infection; Intravitreal angiostrongyliasis; Parastrongylus costaricensis infection; Rat lungworm infection; human eosinophilic meningitis

Networked: 144 relevant articles (8 outcomes, 17 trials/studies)

Relationship Network

Disease Context: Research Results

Infections: 526564
- Parasitic Diseases: 4870
  - Helminthiasis: 527
    - Nematode Infections: 949
      - Secernentea Infections
        Strongylida Infections: 5
        Angiostrongyliasis: 144

Related Diseases

1.	Meningitis
2.	Meningoencephalitis
3.	Pathologic Processes
4.	Demyelinating Diseases (Demyelinating Disease)
5.	Persistent Infection

Experts

1.	Graeff-Teixeira, Carlos: 12 articles (01/2022 - 07/2003)
2.	Maleewong, Wanchai: 10 articles (08/2022 - 12/2002)
3.	Lai, Shih-Chan: 10 articles (04/2022 - 11/2004)
4.	Intapan, Pewpan M: 9 articles (01/2020 - 12/2002)
5.	Chen, Ke-Min: 8 articles (04/2022 - 11/2004)
6.	Tsai, Hung-Chin: 8 articles (01/2021 - 03/2007)
7.	Yen, Chuan-Min: 8 articles (06/2019 - 03/2007)
8.	Wang, Lian-Chen: 7 articles (01/2022 - 02/2006)
9.	Lee, Susan Shin-Jung: 7 articles (06/2019 - 03/2007)
10.	Lai, S C: 7 articles (09/2011 - 07/2004)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Angiostrongyliasis:

1.	Albendazole (Albenza)FDA Link 07/01/2004 - "Albendazole may thus be an effective compound for the treatment of angiostrongyliasis through its larvicidal activity and facilitation of an improved inflammatory response via the reduction of MMP-9 activity." 01/01/2021 - "Administration of albendazole alone was not very suitable for the treatment of cerebral angiostrongyliasis. " 03/01/2013 - "Currently, the drug of choice for treatment of angiostrongyliasis is albendazole, but dead worm lysis causes severe inflammatory response, which leads to central nervous system damage. " 02/01/2006 - "Pathological changes in the brains of the treated rabbits are more severe than those without albendazole treatment, suggesting that the drug may not be very suitable for the treatment of cerebral angiostrongyliasis." 01/01/2011 - "Since no serious adverse effects were observed, a 1-week treatment with a combination of albendazole and dexamethasone appears both safe and beneficial in the treatment of angiostrongyliasis."
2.	Proteins (Proteins, Gene)FDA Link 02/01/2013 - "These findings suggest that this protein plays a role in the pathogenesis of human angiostrongyliasis and is worthy of further study." 07/01/2010 - "The aim of this study was to find novel proteins expressed from an Angiostrongylus cantonensis adult female worm cDNA library for serodiagnosis of angiostrongyliasis. " 01/01/2019 - "The identified proteins may be potential targets for the development of diagnostic or therapeutic agents for human angiostrongyliasis." 11/01/2012 - "cantonensis protein present in crude adult worm extracts is a sensitive and specific method for immunodiagnosis of cerebral angiostrongyliasis. " 01/01/2012 - "In addition to their potential use in angiostrongyliasis diagnosis, characterization of these proteins that establish the host-parasite interphase would improve our understanding of the biology of these parasites. "
3.	ResveratrolIBA 09/01/2017 - "This study investigated the potential function of sirtuin-1 in regulating angiostrongyliasis meningoencephalitis in resveratrol-treated mice. " 09/01/2017 - "Resveratrol treatment was partially beneficial in controlling the pathological processes of angiostrongyliasis meningoencephalitis. "
4.	Dexamethasone (Maxidex)FDA LinkGeneric 01/01/2021 - "Dexamethasone downregulates the expressions of MMP-9 and oxidative stress in mice with eosinophilic meningitis caused by Angiostrongylus cantonensis infection." 04/02/2015 - "Dexamethasone inhibits brain apoptosis in mice with eosinophilic meningitis caused by Angiostrongylus cantonensis infection." 01/01/2011 - "Since no serious adverse effects were observed, a 1-week treatment with a combination of albendazole and dexamethasone appears both safe and beneficial in the treatment of angiostrongyliasis." 01/01/2011 - "Treatment of angiostrongyliasis using a combination of albendazole and dexamethasone: the results of a retrospective and comparative study." 01/01/2011 - "As the information available on the treatment of angiostrongyliasis with a combination of albendazole and dexamethasone is limited, the efficacy of such therapy was assessed using data collected during the 2006 outbreak of angiostrongyliasis in Beijing. "
5.	SteroidsIBA 01/01/2021 - "Steroids have been shown to be beneficial in patients and mice with eosinophilic meningitis caused by Angiostrongylus cantonensis infection; however, the mechanism for this beneficial effect is unknown. "
6.	SolutionsIBA 01/15/2001 - "This larvicidal effect of BW was seen also in incubation times as short as 15 min. In conclusion, the 1.5% bleach solution may be helpful for prophylaxis of human abdominal angiostrongyliasis through disinfection of raw vegetables and unpeeled fruits."
7.	Levamisole (Decaris)FDA Link 01/01/1987 - "The efficacy of the drugs flubendazole, levamisole, and their combination was studied against Angiostrongylus cantonensis infection in mice. " 01/01/1987 - "Experimental chemotherapy of Angiostrongylus cantonensis infection in mice with flubendazole, levamisole, and their combination."
8.	ChitinasesIBA 02/02/2018 - "These reported results constitute a starting point for future research of angiostrongyliasis pathogenesis and imply that targeting chitinases and chitinase-like-proteins may be clinically beneficial in Angiostrongylus cantonensis-induced eosinophilic meningitis."
9.	tribendimidineIBA 03/01/2013 - "Efficacy of tribendimidine against Angiostrongylus cantonensis infection in the mice."
10.	flubendazoleIBA 01/01/1987 - "The efficacy of the drugs flubendazole, levamisole, and their combination was studied against Angiostrongylus cantonensis infection in mice. " 01/01/1987 - "Experimental chemotherapy of Angiostrongylus cantonensis infection in mice with flubendazole, levamisole, and their combination."

Therapies and Procedures

1.	Therapeutics 07/01/2009 - "It is in the initial stage of the study on Angiostrongylus cantonensis and Angiostrongyliasis, and there are a vast space in diagnosis, pathogenic mechanism, therapy and prevalence of Angiostrongyliasis cantonensis." 12/01/2012 - "Therefore, combination therapy with anthelmintics and anti-inflammatory drugs in the treatment of human angiostrongyliasis needs further study. " 11/07/2022 - "The present results provide new insights into the treatment of human angiostrongyliasis using co-therapy with ABZ and calycosin." 01/01/2011 - "As the information available on the treatment of angiostrongyliasis with a combination of albendazole and dexamethasone is limited, the efficacy of such therapy was assessed using data collected during the 2006 outbreak of angiostrongyliasis in Beijing. " 11/07/2022 - "Moreover, co-therapy with ABZ and calycosin failed to mitigate angiostrongyliasis in the presence of tin-protoporphyrin IX, an HO-1-specific inhibitor. "
2.	Vitrectomy 01/01/2018 - "This study reports the first case of intravitreal angiostrongyliasis in South America treated with posterior worm removal via pars plana vitrectomy. "
3.	Drug Therapy (Chemotherapy) 10/15/1971 - "[Chemotherapy of angiostrongyliasis in dogs]." 01/01/1987 - "Experimental chemotherapy of Angiostrongylus cantonensis infection in mice with flubendazole, levamisole, and their combination."
4.	Lasers (Laser) 01/01/2019 - "Focal laser is recommended to eradicate subretinal angiostrongyliasis, while laser treatment prior to surgical removal is recommended to eliminate intracameral and intravitreal angiostrongyliasis. "
5.	Laparotomy 07/01/1995 - "We report here a case of abdominal angiostrongyliasis in a 9-year-old girl, from Itatiba, State of Espirito Santo, Brazil, submitted to exploratory laparotomy for acute abdomen. "