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Clark-Baraitser syndrome

Mental retardation, tall stature, obesity, macrocephaly and typical facial features

Also Known As:

Baraitser Syndrome

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Disease Context: Research Results

Signs and Symptoms Pathological Conditions
- Pathologic Processes: 10023
  - Growth Disorders: 2264
    - Clark-Baraitser syndrome: 1
  - Disease Attributes: 18
    - Facies: 585
      - Clark-Baraitser syndrome: 1
- Signs and Symptoms
  - Body Weight: 130203
    - Overweight: 21719
      - Obesity: 108607
        Clark-Baraitser syndrome: 1
Nervous System Diseases: 14178
- Neurologic Manifestations: 7102
  - Neurobehavioral Manifestations: 1586
    - Intellectual Disability: 8035
      - X-Linked Mental Retardation: 272
        Clark-Baraitser syndrome: 1
- Central Nervous System Diseases: 4213
  - Brain Diseases: 15694
    - Hydrocephalus: 6916
      - Clark-Baraitser syndrome: 1
Nutritional and Metabolic Diseases: 15
- Nutrition Disorders: 404
  - Overnutrition: 616
    - Overweight: 21719
      - Obesity: 108607
        Clark-Baraitser syndrome: 1
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - Nervous System Heredodegenerative Disorders: 63
    - X-Linked Mental Retardation: 272
      - Clark-Baraitser syndrome: 1
  - X-Linked Genetic Diseases: 42
    - X-Linked Mental Retardation: 272
      - Clark-Baraitser syndrome: 1

Related Diseases

1.	Intellectual Disability (Idiocy)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Clark-Baraitser syndrome:

1.	Biomarkers (Surrogate Marker)IBA 11/08/2022 - "We identified a specific and sensitive DNA methylation (DNAm) episignature associated with pathogenic TRIP12 variants, establishing its utility as a clinical biomarker for Clark-Baraitser syndrome. "
2.	Thyroid Hormone Receptors (Thyroid Hormone Receptor)IBA 11/08/2022 - "Clark-Baraitser syndrome is a rare autosomal dominant intellectual disability syndrome caused by pathogenic variants in the TRIP12 (Thyroid Hormone Receptor Interactor 12) gene. "