Myeloid splenomegaly

Spleen enlargement due to the proliferation of MYELOID CELLS and not attributable to another disorder.

Also Known As:

Idiopathic myeloid splenomegaly

Networked: 9 relevant articles (0 outcomes, 2 trials/studies)

1.	Primary Myelofibrosis (Myelosclerosis)
2.	Jaundice (Icterus)
3.	Thrombocytosis (Thrombocythemia)
4.	Splenomegaly
5.	Myeloproliferative Disorders (Myeloproliferative Disorder)

Drugs and Important Biological Agents (IBA) related to Myeloid splenomegaly:

1.	ChromiumIBA 01/01/1956 - "[Hemolytic jaundice & myeloid splenomegaly; efficacity of splenectomy on the hemolytic syndrome; study of the duration of life of erythrocytes by chromium 51 before & after splenectomy]." 09/01/1957 - "[Physiopathologic studies on myeloid splenomegaly with myelofibrosis; studies with radioactive iron and chromium]."
2.	IronIBA 09/01/1957 - "[Physiopathologic studies on myeloid splenomegaly with myelofibrosis; studies with radioactive iron and chromium]."
3.	CytokinesIBA 11/23/2002 - "The hypothesis evoked to explain the appearance of a secondary myelofibrosis is the "inappropriate" secretion, by the malignant plasmocyte clone, of functional analogs of pro-fibrosis cytokines, usually secreted by the mega-caryocyte precursors implied in myeloid splenomegaly."
4.	Immunoglobulin D (IgD)IBA 11/23/2002 - "We report an unusual case of an IgD myeloma revealed in a context of myeloid splenomegaly in a 37 year-old man, initially admitted for severe anaemia associated with a voluminous splenomegaly. "
5.	Histamine (Histamine Dihydrochloride)FDA Link 01/01/1974 - "Blood histamine in the differential diagnosis of myeloid splenomegaly (osteomyelofibrosis) and other myeloproliferative disorders."
6.	Busulfan (Busulfex)FDA Link 01/01/1957 - "[Two cases of myeloid splenomegaly with hemorrhagiparous thrombocythemia; effects of myleran, importance of thromboelastograms]."

1.	Splenectomy 09/01/1960 - "[Hemorrhagic thrombocytemia following splenectomy for myeloid splenomegaly in the adult]." 10/01/1994 - "From 1980 to 1993, 39 splenectomies were performed in the Department of Visceral Surgery of Saint-Louis Hospital, in patients referred for myelofibrosis associated with myeloid splenomegaly. " 01/26/1972 - "[Portal hypertension after splenectomy for myeloid splenomegaly]." 01/01/1956 - "[Hemolytic jaundice & myeloid splenomegaly; efficacity of splenectomy on the hemolytic syndrome; study of the duration of life of erythrocytes by chromium 51 before & after splenectomy]."
2.	Duration of Therapy 01/01/1993 - "Although neither of these two drugs entirely avoids the occurrence of acute leukaemia which appears in 5 to 8% of subjects irrespective of the duration of therapy, on the contrary to observations in patients treated by bleeding alone, myeloid splenomegaly with myelofibrosis is rare and develops in no more than 2% of cases. "