Congenital alopecia X-linked

Congenital cases of alopecia that exhibit X-linked inheritance. OMIM: 300042

Also Known As:

Alopecia congenital; Alopecia, Congenital; Congenital alopecia

Networked: 14 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Skin and Connective Tissue Diseases
- Skin Diseases: 13127
  - Hair Diseases: 36
    - Hypotrichosis: 170
      - Alopecia: 7880
        Congenital alopecia X-linked: 14
Signs and Symptoms Pathological Conditions
- Anatomical Pathological Conditions
  - Alopecia: 7880
    - Congenital alopecia X-linked: 14
Congenital, Hereditary, and Neonatal Diseases and Abnormalities: 933
- Inborn Genetic Diseases: 11939
  - X-Linked Genetic Diseases: 42
    - Congenital alopecia X-linked: 14

Related Diseases

1.	Hypotrichosis
2.	Alopecia (Baldness)
3.	Palmoplantar Keratoderma (Keratosis Palmaris et Plantaris)
4.	Burns
5.	Congenital Microtia

Experts

1.	Jiang, Xingyuan: 1 article (10/2022)
2.	Lee, Mingyang: 1 article (10/2022)
3.	Li, Qian: 1 article (10/2022)
4.	Lin, Mao-Ying: 1 article (10/2022)
5.	Lin, Zhimiao: 1 article (10/2022)
6.	Wang, Huijun: 1 article (10/2022)
7.	Xu, Zhengren: 1 article (10/2022)
8.	Yang, Fang: 1 article (10/2022)
9.	Zhang, Jianglin: 1 article (10/2022)
10.	Zhu, Yuhao: 1 article (10/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Congenital alopecia X-linked:

1.	Minoxidil (Rogaine)FDA LinkGeneric 04/01/2013 - "Topical minoxidil treatment for congenital alopecia in hypohidrotic ectodermal dysplasia." 11/01/2019 - "Topical minoxidil may be effective in management of congenital alopecia and hypotrichosis associated with desmoplakin mutations." 11/01/2019 - "Herein, we present an 8-year-old boy, with a combination of two heterozygous mutations in the DSP gene encoding desmoplakin associated with congenital alopecia and long-standing hypotrichosis, who was treated with off-label use of topical minoxidil 5% foam once daily with dramatic growth after 2 months of therapy and sustained results at 1 year. "
2.	Desmoplakins (Desmoplakin)IBA 11/01/2019 - "Topical minoxidil may be effective in management of congenital alopecia and hypotrichosis associated with desmoplakin mutations." 11/01/2019 - "Syndromes associated with desmosomal protein mutations such as desmoplakin can result in hair abnormalities including congenital alopecia and hypotrichosis. " 11/01/2019 - "Herein, we present an 8-year-old boy, with a combination of two heterozygous mutations in the DSP gene encoding desmoplakin associated with congenital alopecia and long-standing hypotrichosis, who was treated with off-label use of topical minoxidil 5% foam once daily with dramatic growth after 2 months of therapy and sustained results at 1 year. "
3.	Keratins (Keratin)IBA 02/01/2021 - "A rare form of congenital alopecia resulting in follicular dystrophy is described in cats which is similar to hair follicle and hair-shaft changes reported in several mutant mouse strains with single gene mutations in adhesion molecules or keratin genes. " 12/01/2020 - "Autosomal recessive woolly hair/hypotrichosis (ARWH/H) is a rare form of congenital alopecia, which can be caused by mutations in lipase H (LIPH), lysophosphatidic acid receptor 6 (LPAR6/P2RY5) or keratin 25 (KRT25) genes. "
4.	EctodysplasinsIBA 11/01/2023 - "Congenital alopecia often has a hereditary cause, and examples of such disorders are ectodermal dysplasias associated with gene variants of the ectodysplasin A gene. "
5.	Lysophosphatidic Acid ReceptorsIBA 12/01/2020 - "Autosomal recessive woolly hair/hypotrichosis (ARWH/H) is a rare form of congenital alopecia, which can be caused by mutations in lipase H (LIPH), lysophosphatidic acid receptor 6 (LPAR6/P2RY5) or keratin 25 (KRT25) genes. "
6.	Acitretin FDA Link 03/01/2019 - "Resolution of pseudoainhum with acitretin therapy in a patient with palmoplantar keratoderma and congenital alopecia."
7.	Proteins (Proteins, Gene)FDA Link 11/01/2019 - "Syndromes associated with desmosomal protein mutations such as desmoplakin can result in hair abnormalities including congenital alopecia and hypotrichosis. "
8.	Lipase (Acid Lipase)FDA Link 12/01/2020 - "Autosomal recessive woolly hair/hypotrichosis (ARWH/H) is a rare form of congenital alopecia, which can be caused by mutations in lipase H (LIPH), lysophosphatidic acid receptor 6 (LPAR6/P2RY5) or keratin 25 (KRT25) genes. "
9.	DNA (Deoxyribonucleic Acid)IBA 10/01/1998 - "Determining the exon-intron structure allowed detailed mutational analysis of DNA samples of patients with universal congenital alopecia. "
10.	CholesterolIBA 10/01/2022 - "Taken together, our findings indicate LSS as a causative gene for palmoplantar keratoderma-congenital alopecia syndrome type 2, which emphasizes the importance of the cholesterol synthesis pathway in human skin cornification."

Therapies and Procedures

1.	Transplantation 02/01/1979 - "Hair transplantation for congenital alopecia." 09/01/2003 - "The most common causes for aesthetic hair restoration of those areas in the author's experience include hair loss resulting from aesthetic facial rejuvenation surgery, revision of unsatisfactory results from previous hair transplantation, burn alopecia, congenital reasons, and hair loss after oncologic resections. "
2.	Therapeutics 03/01/2019 - "Resolution of pseudoainhum with acitretin therapy in a patient with palmoplantar keratoderma and congenital alopecia." 11/01/2019 - "Herein, we present an 8-year-old boy, with a combination of two heterozygous mutations in the DSP gene encoding desmoplakin associated with congenital alopecia and long-standing hypotrichosis, who was treated with off-label use of topical minoxidil 5% foam once daily with dramatic growth after 2 months of therapy and sustained results at 1 year. "
3.	Off-Label Use 11/01/2019 - "Herein, we present an 8-year-old boy, with a combination of two heterozygous mutations in the DSP gene encoding desmoplakin associated with congenital alopecia and long-standing hypotrichosis, who was treated with off-label use of topical minoxidil 5% foam once daily with dramatic growth after 2 months of therapy and sustained results at 1 year. "
4.	Tissue Expansion 05/01/1986 - "Use of temporary soft-tissue expansion in five patients with posttraumatic alopecia and one patient with congenital alopecia is presented. "
5.	Tissue Expansion Devices (Tissue Expander) 10/01/1991 - "The most frequent indications for the use of tissue expanders included congenital nevi and burn scars, they were also used with success in alopecia, congenital abdominal wall defects, mammary hypoplasia and microtia. "