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Thiel-Behnke type Corneal dystrophy

Also Known As:
Corneal dystrophy, Thiel-Behnke type; Corneal Dystrophy Of Bowman Layer, Type II; Corneal Dystrophy, Honeycomb-Shaped; Corneal dystrophy honeycomb-shaped; Corneal dystrophy of the Bowman layer, type 2; Thiel-Behnke corneal dystrophy
Networked: 10 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1. Hereditary Corneal Dystrophies
2. Corneal dystrophy Avellino type
3. Corneal Opacity

Experts

1. Yee, Richard W: 2 articles (01/2005 - 10/2003)
2. Yee, Steven B: 2 articles (01/2005 - 10/2003)
3. Abusayf, Mohammed M: 1 article (06/2022)
4. Alfawaz, Abdullah: 1 article (06/2022)
5. Alkatan, Hind M: 1 article (06/2022)
6. Tobaigy, Mohannad F: 1 article (06/2022)
7. Liu, Hanruo: 1 article (01/2022)
8. Liu, Ping: 1 article (01/2022)
9. Tang, Xianling: 1 article (01/2022)
10. Wang, Liyuan: 1 article (01/2022)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Thiel-Behnke type Corneal dystrophy:
1. Transforming Growth Factor beta (TGF-beta)IBA
01/01/2022 - "Thiel-Behnke corneal dystrophy (TBCD) is an epithelial-stromal TGFBI dystrophy caused by mutations in the TGFBI (transforming growth factor beta induced) gene, though the underlying mechanisms and pathogenesis of TBCD are still obscure. "
10/01/2010 - "To investigate the transforming growth factor beta induced (TGFBI; BIGH3) gene mutation and founder effect of two large Chinese families clinically diagnosed as Thiel-Behnke corneal dystrophy. "
05/01/2009 - "To analyze transforming growth factor beta-induced (TGFBI) gene mutations in 2 Chinese families with Thiel-Behnke corneal dystrophy (TBCD). "
01/01/2007 - "Two patients from one pedigree (a 29-year-old woman and 58-year-old man) with Thiel-Behnke corneal dystrophy (Arg555Gln [R555Q] heterozygous missense mutation of human transforming growth factor beta-induced [TGFBI] gene) and 3 patients from one pedigree (a 70-year-old woman, 58-year-old man, and 14-year old man) with Reis-Bücklers corneal dystrophy (Arg124Leu [R124L] heterozygous missense mutation of the TGFBI gene) were examined. "
01/01/2022 - " AS-OCT: anterior segment optical coherence tomography; ATP: adenosine triphosphate; Cas9: CRISPR-associated protein 9; CLEAR: coordinated lysosomal expression and regulation; CRISPR: clustered regularly interspaced short palindromic repeats; CTSB: cathepsin B; CTSD: cathepsin D; CTSF: cathepsin F; CTSL: cathepsin L; DNA: deoxyribonucleic acid; ECM: extracellular matrix; Fas1: fasciclin 1; FC: flow cytometry; GAPDH: glyceraldeyde-3-phosphate dehydrogenase; GCD2: granular corneal dystrophy type 2; HE: hematoxylin and eosin; LAMP2: lysosomal-associated membrane protein; MT: mutation type; MTOR: mechanistic target of rapamycin kinase; MTORC1: MTOR complex 1; mut-TGFBI: mutant TGFBI protein; SD: standard deviation; TBCD: Thiel-Behnke corneal dystrophy; TEM: transmission electron microscopy; TFEB: transcription factor EB; TGFBI: transforming growth factor beta induced; WT: wild type."
2. DNA (Deoxyribonucleic Acid)IBA
3. Cathepsin LIBA
4. Cathepsin FIBA
5. Lysosomal Membrane ProteinsIBA
6. Sirolimus (Rapamycin)FDA Link
7. Transcription Factors (Transcription Factor)IBA
8. Phosphotransferases (Kinase)IBA
9. Oxidoreductases (Dehydrogenase)IBA
10. Hematoxylin (Haematoxylon)IBA

Therapies and Procedures

1. Keratectomy
2. Excimer Lasers
3. Photorefractive Keratectomy
4. Penetrating Keratoplasty
5. Lasers (Laser)